| CA 19-9 Levels Were in Relation to Different Glucose Regulation Status in a Middle-aged and Elderly Chinese Population. | |
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MedLine Citation:
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PMID: 22176810 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To investigate carbohydrate antigen (CA) 19-9 levels in subjects with different glucose regulation status and assess the relationship between CA 19-9 and glucose regulation status in a Chinese population aged 40 years and older. Methods: A total of 2792 participants aged 40 or older without history of diabetes were enrolled in the present study from Songnan region, Shanghai, China. Each participant received a two-point (0 and 2h) 75-g oral glucose tolerance test (OGTT) and measurements of hemoglobin A1c (HbA1c) and CA 19-9. Results: CA19-9 levels increased gradually from normal glucose regulation (NGR), impaired glucose regulation (IGR) to new-onset diabetic patients (8.81, 9.84 and 11.08 U/mL, P for trend <0.0001). In new-onset diabetic patients, CA 19-9 levels were positively and significantly associated with FPG (r=0.20, P<0.0001), PPG (r=0.17, P=0.0007) and HbA1c (r=0.19, P=0.0001). Meanwhile, patients with new-onset diabetes had 3.31-fold (OR, 4.31; 95% CI, 2.00-9.32) increased higher odds ratio of elevated CA 19-9 as compared with those with NGR after adjustments for confounders. Conclusion: CA 19-9 levels were significantly higher in diabetic and IGR patients as compared with subjects with NGR. Diabetic status was independently associated with elevated CA 19-9. These results imply that CA19-9 might also relate to endocrine function of pancreas. |
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Authors:
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Yun Huang; Yu Xu; Yufang Bi; Min Xu; Jieli Lu; Tiange Wang; Mian Li; Yuhong Chen; Yu Liu; Fei Huang; Baihui Xu; Jie Zhang; Weiqing Wang; Guang Ning |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-18 |
Journal Detail:
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Title: Journal of diabetes Volume: - ISSN: 1753-0407 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504326 Medline TA: J Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Ruijin Hospital and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, 200025 China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025 China. |
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