| CA-125 response patterns in patients with recurrent ovarian cancer treated with pegylated liposomal doxorubicin (PLD). | |
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MedLine Citation:
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PMID: 20130507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION:: In recurrent ovarian cancer, CA-125 could be the only objective response criteria. This study analyzes response patterns regarding CA-125 in responders versus nonresponders and determines whether a specific cutoff value for CA-125 could predict clinical response, compared with response evaluation criteria in solid tumors, in patients receiving pegylated liposomal doxorubicin (PLD). METHODS:: Sixty-eight patients were identified, 78% were platinum resistant. Relative changes in CA-125 values were calculated, and response was defined as higher than 50% reduction in CA-125 from baseline. Receiver operating characteristic (ROC) curves were constructed based on CA-125 value after the first cycle of PLD to evaluate the most precise cutoff point for the decision model predicting response. RESULTS:: Fifty-three patients were assessable for response: 16 patients responded and 37 did not; the median increase of CA-125 was 0.20 (-63; 312) and 52 (-29; 620), respectively. Our ROC curve generated a cutoff value with a sensitivity of 35% (positive test, the proportion of patients who will not respond) and a predictive positive value of 80%. According to the predictive positive value, 20% of the responder patients will be identified as nonresponders; P = 0.025. CONCLUSIONS:: Our ROC analysis did not demonstrate any reliable CA-125 cutoff on response. Discontinuation of the therapy before cycle 3 may exclude some patients who will benefit from PLD. |
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Authors:
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Ana Oaknin; Pilar Barretina; Xavier P?rez; Laura Jimenez; Montserrat Velasco; Maria Alsina; Joan Brunet; Josep Ramon Germ?; Miguel Beltran |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 20 ISSN: 1525-1438 ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 87-91 Citation Subset: IM |
Affiliation:
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Gynecology Cancer Unit, Oncology Department, Vall d'Hebron University Hospital, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain. amoaknin@vhebron.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antibiotics, Antineoplastic / administration & dosage, chemistry Biomarkers, Pharmacological / blood, metabolism CA-125 Antigen / blood* Cystadenocarcinoma, Serous / blood*, diagnosis, drug therapy* Doxorubicin / administration & dosage*, chemistry Female Humans Liposomes Middle Aged Ovarian Neoplasms / blood*, diagnosis, drug therapy* Polyethylene Glycols / chemistry Predictive Value of Tests Prognosis ROC Curve Recurrence Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Biomarkers, Pharmacological; 0/CA-125 Antigen; 0/Liposomes; 0/Polyethylene Glycols; 23214-92-8/Doxorubicin |
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