Document Detail

CA 125 in the epithelium closely related to the embryonic ectoderm: the periderm and the amnion.
MedLine Citation:
PMID:  2669495     Owner:  NLM     Status:  MEDLINE    
The amnion is believed to be derived from either cytotrophoblastic cells or embryonic ectoderm. However, it produces and secretes CA 125, which is considered a differentiation antigen of fetal coelomic epithelium derived from the mesoderm of germ cells. To verify this, the immunohistochemical localization of CA 125 in human fetal tissues (between 7 and 23 weeks of gestation) derived from the ectoderm, endoderm, or mesoderm, and in the fetal membranes and placenta was studied. Among the mesoderm-derived tissues, only the fetal coelomic epithelium-related tissues were positive for anti-CA 125 from 15 weeks of gestation. The endoderm-derived tissues did not react with anti-CA 125. However, among the ectoderm-derived tissues, only the periderm reacted with anti-CA 125 from 7 weeks until it sloughed from the stratum intermedium by 23 weeks of gestation. Among the fetal membranes and placenta, only the amnion reacted with anti-CA 125 from 9 weeks to term. These findings indicate that the amnion and the periderm, both of which constitute the epithelia covering the amniotic cavity, in addition to the fetal coelomic epithelium-related tissues, produce CA 125.
Y Nanbu; S Fujii; I Konishi; H Nonogaki; T Mori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  161     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-13     Completed Date:  1989-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  462-7     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Amnion / immunology*
Antigens, Tumor-Associated, Carbohydrate / analysis*
Ectoderm / immunology*
Endoderm / immunology
Epithelium / immunology
Extraembryonic Membranes / immunology
Gestational Age
Immunoenzyme Techniques
Mesoderm / immunology
Placenta / immunology
Reg. No./Substance:
0/Antigens, Tumor-Associated, Carbohydrate

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