| CA 125 in the epithelium closely related to the embryonic ectoderm: the periderm and the amnion. | |
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MedLine Citation:
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PMID: 2669495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The amnion is believed to be derived from either cytotrophoblastic cells or embryonic ectoderm. However, it produces and secretes CA 125, which is considered a differentiation antigen of fetal coelomic epithelium derived from the mesoderm of germ cells. To verify this, the immunohistochemical localization of CA 125 in human fetal tissues (between 7 and 23 weeks of gestation) derived from the ectoderm, endoderm, or mesoderm, and in the fetal membranes and placenta was studied. Among the mesoderm-derived tissues, only the fetal coelomic epithelium-related tissues were positive for anti-CA 125 from 15 weeks of gestation. The endoderm-derived tissues did not react with anti-CA 125. However, among the ectoderm-derived tissues, only the periderm reacted with anti-CA 125 from 7 weeks until it sloughed from the stratum intermedium by 23 weeks of gestation. Among the fetal membranes and placenta, only the amnion reacted with anti-CA 125 from 9 weeks to term. These findings indicate that the amnion and the periderm, both of which constitute the epithelia covering the amniotic cavity, in addition to the fetal coelomic epithelium-related tissues, produce CA 125. |
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Authors:
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Y Nanbu; S Fujii; I Konishi; H Nonogaki; T Mori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 161 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-13 Completed Date: 1989-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 462-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amnion
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immunology* Antigens, Tumor-Associated, Carbohydrate / analysis* Ectoderm / immunology* Endoderm / immunology Epithelium / immunology Extraembryonic Membranes / immunology Female Gestational Age Humans Immunoenzyme Techniques Immunohistochemistry Male Mesoderm / immunology Placenta / immunology Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Tumor-Associated, Carbohydrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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