| C4 null genes in American whites and blacks with myositis. | |
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MedLine Citation:
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PMID: 2332854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequencies of C4A and C4B alleles were determined in 66 adults with myositis in relation to HLA class I and II. In whites with myositis, the C4A*Q0 allele occurred in 13/31 (47%) as compared to 25/101 (25%) normal controls (p = 0.08, relative risk = 2.7). Only 11/35 (31%) of black patients with myositis had a C4A*Q0 allele compared to 11/55 (20%) of controls (p = NS, RR = 1.8). Thus, the MHC class III genes do not appear to be the primary genetic risk factors for myositis in adults. |
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Authors:
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J M Moulds; C Rolih; R Goldstein; K F Whittington; N B Warner; I N Targoff; M Reichlin; F C Arnett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of rheumatology Volume: 17 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-06-05 Completed Date: 1990-06-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 331-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Texas Medical School, Houston 77225. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group
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genetics* Alleles* Chromosome Deletion Complement C4 / genetics* Dermatomyositis / ethnology, genetics, immunology European Continental Ancestry Group / genetics* Genes* HLA Antigens / analysis, genetics Humans Myositis / ethnology, genetics*, immunology Phenotype United States |
| Grant Support | |
ID/Acronym/Agency:
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2R01AR32214-04A2/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Complement C4; 0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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