Document Detail

C4 nephritic factor in a patient with chronic glomerulonephritis.
MedLine Citation:
PMID:  3298656     Owner:  NLM     Status:  MEDLINE    
C4 nephritic factor (C4NeF) was found in the serum of a patient with chronic glomerulonephritis, whose C3 level was quite low (less than 1% of normal). C4NeF prevented the intrinsic decay of C4b2a enzyme and prolonged the half life of the C4b2a from several minutes to more than 1 h in the solid and fluid phase. The C4NeF activity was associated with a protein fraction immunochemically identified as the IgG3 subclass and it bound specifically to the EAC142 cells. In addition, the patient's serum contained C3-cleaving activity, probably C4b2a, C4NeF complex, which may have lowered the level of C3 in the patient's serum. Spontaneously, the titer of C4NeF decreased, while the level of C3 increased.
T Fujita; T Sumita; S Yoshida; S Ito; N Tamura
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  22     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-08-11     Completed Date:  1987-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Complement C3 / metabolism
Complement C4 / metabolism
Electrophoresis, Polyacrylamide Gel
Glomerulonephritis / immunology*
Hemolytic Plaque Technique
Middle Aged
Reg. No./Substance:
0/Complement C3; 0/Complement C4

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