Document Detail


C4 nephritic factor in a patient with chronic glomerulonephritis.
MedLine Citation:
PMID:  3298656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C4 nephritic factor (C4NeF) was found in the serum of a patient with chronic glomerulonephritis, whose C3 level was quite low (less than 1% of normal). C4NeF prevented the intrinsic decay of C4b2a enzyme and prolonged the half life of the C4b2a from several minutes to more than 1 h in the solid and fluid phase. The C4NeF activity was associated with a protein fraction immunochemically identified as the IgG3 subclass and it bound specifically to the EAC142 cells. In addition, the patient's serum contained C3-cleaving activity, probably C4b2a, C4NeF complex, which may have lowered the level of C3 in the patient's serum. Spontaneously, the titer of C4NeF decreased, while the level of C3 increased.
Authors:
T Fujita; T Sumita; S Yoshida; S Ito; N Tamura
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  22     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-08-11     Completed Date:  1987-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Complement C3 / metabolism
Complement C4 / metabolism
Electrophoresis, Polyacrylamide Gel
Female
Glomerulonephritis / immunology*
Hemolytic Plaque Technique
Humans
Immunochemistry
Middle Aged
Chemical
Reg. No./Substance:
0/Complement C3; 0/Complement C4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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