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C2-Symmetric Cyclic Selenium Catalyzed Enantioselective Bromoaminocyclization.
MedLine Citation:
PMID:  23312005     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A catalytic asymmetric bromocyclization of tri-substituted olefinic amides is reported using a C2-symmetric mannitol-derived cyclic selenium catalyst and stoichiometric amount of N-bromophthalimide. The resulting enantioenriched pyrrolidine products, which contain two stereogenic centers, could undergo rearrangement to yield 2,3-disubstituted piperidine in excellent diastereoselectivity and enantiospecificity.
Authors:
Feng Chen; Chong Kiat Tan; Ying-Yeung Yeung
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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