| C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages. | |
| | |
MedLine Citation:
|
PMID: 20652496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
C1qTNF-Related proteins (CTRPs), a new highly conserved family of adiponectin paralogs, were recently identified as being involved in diverse processes including metabolism, host defense, apoptosis, cell differentiation, and organogenesis. However, the functional role of CTRP6 remains poorly identified. Here we provide evidence that CTRP6 induces the expression of interleukin-10 (IL-10) in macrophages. Conditioned medium from CTRP6-expressing HEK293 cells increased IL-10 expression in Raw264.7 cells. The globular domain of CTRP6 (gCTRP6) also dose-dependently increased both IL-10 mRNA and protein expression levels, with transcript levels increasing within 2 h. Furthermore, the globular domain of CTRP6 rapidly induced phosphorylation of ERK1/2 in Raw264.7 cells. Treatment with U0126, a selective inhibitor, abolished CTRP6-stimulated IL-10 induction. Taken together, there results demonstrate that CTRP6 induces expression of IL-10 via ERK1/2 activation. Considering that IL-10 is a potent anti-inflammatory cytokine that modulates inflammatory signaling pathways, CTRP6 may be a novel target for pharmacological drugs in inflammatory diseases. |
| | |
Authors:
|
Mi-Jin Kim; Wan Lee; Eun-Ju Park; Seung-Yoon Park |
Related Documents
:
|
20674506 - Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production ... 15008976 - Pct-233, a novel modulator of pro- and anti-inflammatory cytokine production. 11028556 - Gender-related therapy: early il-10 administration after hemorrhage restores immune fun... 12516776 - Stimulation of the secretion of pro-inflammatory cytokines by bifidobacterium strains. 11686006 - The role of high-density lipoproteins in oxidation and inflammation. 306666 - Macrophage activation by lymphokines and after direct contact with sensitized lymphocyt... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-14 |
Journal Detail:
|
Title: Molecules and cells Volume: 30 ISSN: 0219-1032 ISO Abbreviation: Mol. Cells Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-23 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9610936 Medline TA: Mol Cells Country: United States |
Other Details:
|
Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, School of Medicine, Dongguk University, Kyungju 780-714, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Line HEK293 Cells Humans Interleukin-10 / biosynthesis* MAP Kinase Signaling System Macrophages / metabolism*, physiology Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Phosphorylation Proteins / genetics, metabolism* Signal Transduction Transfection |
| Chemical | |
Reg. No./Substance:
|
0/C1QTNF1 protein, human; 0/Proteins; 130068-27-8/Interleukin-10; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Suppression of lipopolysaccharide-induced microglial activation by a benzothiazole derivative.
Next Document: A conserved motif controls nuclear localization of Drosophila Muscleblind.