Document Detail

C1q: the perfect complement for a synaptic feast?
MedLine Citation:
PMID:  18827829     Owner:  NLM     Status:  MEDLINE    
The efficient and selective removal of apoptotic cells is an important feature of tissue development, homeostasis and pathology. In the nervous system, synapses and distal axons are selectively eliminated as part of the remodelling that underpins development and pathology, through a process that has some features in common with apoptotic cell removal. Components of the complement cascade are implicated in the efficient removal of apoptotic cells outside the nervous system, and recent evidence suggests that the complement components C1q and C3 have a role in the selective tagging of supernumerary synapses in the developing visual system and in their efficient removal by as yet unidentified cells.
V Hugh Perry; Vincent O'Connor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-10-01
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  9     ISSN:  1471-0048     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-11-06     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  807-11     Citation Subset:  IM    
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MeSH Terms
Complement C1q / genetics,  metabolism*
Neuronal Plasticity / physiology
Neurons / physiology
Synapses / metabolism*
Grant Support
G0501636//Medical Research Council; //Medical Research Council
Reg. No./Substance:
80295-33-6/Complement C1q

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