Document Detail


C1q: the perfect complement for a synaptic feast?
MedLine Citation:
PMID:  18827829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficient and selective removal of apoptotic cells is an important feature of tissue development, homeostasis and pathology. In the nervous system, synapses and distal axons are selectively eliminated as part of the remodelling that underpins development and pathology, through a process that has some features in common with apoptotic cell removal. Components of the complement cascade are implicated in the efficient removal of apoptotic cells outside the nervous system, and recent evidence suggests that the complement components C1q and C3 have a role in the selective tagging of supernumerary synapses in the developing visual system and in their efficient removal by as yet unidentified cells.
Authors:
V Hugh Perry; Vincent O'Connor
Related Documents :
19709599 - Direct toxicity of rose bengal in mcf-7 cell line: role of apoptosis.
7935379 - Tissue transglutaminase and apoptosis: sense and antisense transfection studies with hu...
15455089 - Effects of phosphoinositide cycle modifiers on apoptosis of peritoneal macrophages.
15099759 - Flow cytometric evaluation of a model for phagocytosis of cells undergoing apoptosis.
16187279 - A novel role for placental leucine aminopeptidase (p-lap) as a determinant of chemoresi...
2317949 - Hl-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis.
7404269 - Isolation of mouse cell lines resistant to the fusion-inducing effect of polyethylene g...
19473699 - Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells.
9294649 - Immunolocalization of androgen receptor and estrogen receptor in the developing testis ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-10-01
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  9     ISSN:  1471-0048     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-11-06     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  807-11     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Complement C1q / genetics,  metabolism*
Humans
Neuronal Plasticity / physiology
Neurons / physiology
Synapses / metabolism*
Grant Support
ID/Acronym/Agency:
G0501636//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
80295-33-6/Complement C1q

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Therapeutic application of histone deacetylase inhibitors for central nervous system disorders.
Next Document:  Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest...