Document Detail

C1q nephropathy in the pediatric population: pathology and pathogenesis.
MedLine Citation:
PMID:  20180137     Owner:  NLM     Status:  MEDLINE    
C1q nephropathy was originally described nearly 25 years ago by Jennette and Hipp. Since that time there have been a limited number of publications on C1q nephropathy, most of them in the pediatric literature. Despite reported incidences as high as 16% in some pediatric biopsy series, a consensus definition on the diagnosis of C1q nephropathy is lacking and its existence as a distinct clinical disease entity remains controversial. The purpose of this review is to discuss the biology of C1q in the context of mechanisms of C1q deposition, and to provide a detailed analysis of the published pediatric case series with a focus on the pathological criteria used to establish the diagnosis of C1q nephropathy as well as long-term outcomes in children.
Scott E Wenderfer; Rita D Swinford; Michael C Braun
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-24
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  25     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1385-96     Citation Subset:  IM    
Division of Pediatric Nephrology and Hypertension, Department of Pediatrics, University of Texas School of Medicine, Houston, USA.
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MeSH Terms
Chronic Disease
Glomerulonephritis / diagnosis*,  pathology*
Kidney Diseases / pathology*
Population Groups

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