| The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water. | |
| | |
MedLine Citation:
|
PMID: 2786886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques. |
| | |
Authors:
|
A A Lammertsma; R S Frackowiak; J M Hoffman; S C Huang; I N Weinberg; M Dahlbom; N S MacDonald; E J Hoffman; J C Mazziotta; J D Heather |
Related Documents
:
|
4055096 - Properties of new sorbents containing activated carbon-phema-peg. 17730136 - Aircraft monitoring of surface carbon dioxide exchange. 21242026 - Identification and fate of halogenated pahs formed during electrochemical treatment of ... 8627476 - Viability of infective larvae of haemonchus contortus, ostertagia ostertagi, and tricho... 10704896 - Allopurinol encapsulated in polycyanoacrylate nanoparticles as potential lysosomatropic... 10831056 - Ultrastructural study of spermiogenesis and the spermatozoon in catenotaenia pusilla, a... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 9 ISSN: 0271-678X ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 1989 Aug |
Date Detail:
|
Created Date: 1989-08-08 Completed Date: 1989-08-08 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 461-70 Citation Subset: IM |
Affiliation:
|
Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Brain / blood supply*, metabolism, radionuclide imaging Carbon Radioisotopes / diagnostic use Humans Male Oxygen Radioisotopes / diagnostic use Regional Blood Flow Tomography, Emission-Computed / methods Water / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
MH 37916/MH/NIMH NIH HHS; NS15654/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Radioisotopes; 0/Oxygen Radioisotopes; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Estimation of local cerebral protein synthesis rates with L-[1-11C]leucine and PET: methods, model, ...
Next Document: Interleukin-1-induced anorexia in the rat. Influence of prostaglandins.