| C11-acetate and F-18 FDG PET for men with prostate cancer bone metastases: relative findings and response to therapy. | |
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MedLine Citation:
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PMID: 21285676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF THE REPORT: This study tested the feasibility of C11-acetate (acetate) positron emission tomography (PET) imaging to assess response to therapy in men with bone metastatic prostate cancer and compared results for disease detection and response evaluation with F-18 fluorodeoxyglucose (FDG) PET. MATERIALS AND METHODS: Men with ≥3 prostate cancer bone metastases identified by Tc-99m methylene diphosphonate (MDP) bone scintigraphy and/or computed tomography were enrolled in a prospective study of serial acetate and FDG PET imaging. Patients were imaged before and 6 to 12 weeks after initial androgen deprivation therapy for new metastatic prostate cancer or first-line chemotherapy with docetaxel for castration-resistant prostate cancer. Qualitative assessment and changes in the tumor:normal uptake ratio were used to assess response by both acetate and FDG PET. In addition, the detection of bone metastases pretherapy was compared for acetate and FDG PET. RESULTS: A total of 8 patients with documented bone metastases were imaged, of which 6 were imaged both pre- and post-therapy. Acetate PET detected bone metastases in all 8 patients, whereas FDG PET detected lesions in 6 of the 7 imaged patients. Acetate PET generally detected more metastases with a higher tumor:normal uptake ratio. Qualitative and quantitative assessments of post-treatment response correlated with composite clinical designations of response, stable disease, or progression in 6 of 6 and 5 of 6 by acetate and 4 of 5 and 3 of 5 by FDG PET, respectively. CONCLUSIONS: In this pilot study, results indicate that acetate PET holds promise for response assessment of prostate cancer bone metastases and is complementary to FDG PET in bone metastasis detection. |
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Authors:
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Evan Y Yu; Mark Muzi; Joy A Hackenbracht; Brian B Rezvani; Jeanne M Link; Robert Bruce Montgomery; Celestia S Higano; Janet F Eary; David A Mankoff |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-02 Completed Date: 2011-05-18 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 192-8 Citation Subset: IM |
Affiliation:
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Division of Oncology, Department of Medicine, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. evanyu@uw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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diagnostic use* Bone Neoplasms / radionuclide imaging*, secondary* Carbon / diagnostic use* Fluorodeoxyglucose F18 / diagnostic use* Humans Male Positron-Emission Tomography* Prostatic Neoplasms / drug therapy*, pathology*, radionuclide imaging Taxoids / therapeutic use Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA042045-13/CA/NCI NIH HHS; P01-CA42045/CA/NCI NIH HHS; P30 CA015704-26/CA/NCI NIH HHS; P30-CA015704/CA/NCI NIH HHS; P50 CA097186-01/CA/NCI NIH HHS; P50-CA97186/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Taxoids; 0/carbon-11 acetate; 114977-28-5/docetaxel; 63503-12-8/Fluorodeoxyglucose F18; 7440-44-0/Carbon |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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