Document Detail

C-type natriuretic peptide in the human central nervous system: distribution and molecular form.
MedLine Citation:
PMID:  8015979     Owner:  NLM     Status:  MEDLINE    
The distribution and molecular form of C-type natriuretic peptide (CNP) in the human central nervous system were studied with a specific radioimmunoassay for CNP-22. Immunoreactive (IR-) CNP was detectable in all regions of the brain examined (cerebral cortex, thalamus, hypothalamus, pons, and cerebellum) (0.21-0.81 pmol/g wet tissue, n = 4). The highest concentration of IR-CNP was found in the spinal cord at 1.83 +/- 0.13 pmol/g wet tissue (mean +/- SD, n = 3). Reversed-phase high performance liquid chromatography revealed a major peak migrating at the position corresponding to synthetic human CNP-53 and minor peaks comigrating with synthetic CNP-22 and the methionine-oxidized form of CNP-22, respectively. These findings suggest that IR-CNP is widely present in the human central nervous system mainly in a high molecular weight form as the major component and in the molecular form of CNP-22 as the minor component.
K Totsune; K Takahashi; M Ohneda; K Itoi; O Murakami; T Mouri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  15     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-07-26     Completed Date:  1994-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Atrial Natriuretic Factor / analysis*,  chemistry
Central Nervous System / chemistry*
Chromatography, Gel
Chromatography, High Pressure Liquid
Natriuretic Peptide, C-Type
Nerve Tissue Proteins / analysis*,  chemistry
Reg. No./Substance:
0/Nerve Tissue Proteins; 127869-51-6/Natriuretic Peptide, C-Type; 85637-73-6/Atrial Natriuretic Factor

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