Document Detail

C-terminal octapeptide of cholecystokinin decreases food intake in obese men.
MedLine Citation:
PMID:  6294699     Owner:  NLM     Status:  MEDLINE    
Six of eight obese men ate significantly less food during an intravenous infusion of the C-terminal octapeptide of cholecystokinin (CCK-8, 4 ng . kg-1 . min-1) than during a saline infusion in a double blind experimental paradigm. Subjects stopped eating sooner during CCK-8. CCK-8 did not change the rate of eating. No overt side effects were reported or observed. This is the first report of the satiety effect of CCK-8 in obese humans and it suggests that the therapeutic potential of CCK-8 for the treatment of obesity deserves investigation.
X Pi-Sunyer; H R Kissileff; J Thornton; G P Smith
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  29     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  627-30     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects*
Cholecystokinin / therapeutic use*
Eating / drug effects*
Energy Intake / drug effects
Obesity / drug therapy*
Peptide Fragments / therapeutic use*
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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