| C-terminal octapeptide of cholecystokinin decreases food intake in obese men. | |
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MedLine Citation:
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PMID: 6294699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six of eight obese men ate significantly less food during an intravenous infusion of the C-terminal octapeptide of cholecystokinin (CCK-8, 4 ng . kg-1 . min-1) than during a saline infusion in a double blind experimental paradigm. Subjects stopped eating sooner during CCK-8. CCK-8 did not change the rate of eating. No overt side effects were reported or observed. This is the first report of the satiety effect of CCK-8 in obese humans and it suggests that the therapeutic potential of CCK-8 for the treatment of obesity deserves investigation. |
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Authors:
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X Pi-Sunyer; H R Kissileff; J Thornton; G P Smith |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 29 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-02-14 Completed Date: 1983-02-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 627-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Weight
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drug effects* Cholecystokinin / therapeutic use* Eating / drug effects* Energy Intake / drug effects Humans Male Obesity / drug therapy* Peptide Fragments / therapeutic use* Sincalide |
| Grant Support | |
ID/Acronym/Agency:
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AM 26687/AM/NIADDK NIH HHS; MH 00149/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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