Document Detail

C-terminal octapeptide of cholecystokinin decreases food intake in man.
MedLine Citation:
PMID:  6259918     Owner:  NLM     Status:  MEDLINE    
In comparison with a saline infusion, the infusion of the C-terminal octapeptide of cholecystokinin (4 ng/kg/min) decreased food intake by an average of 122 g in a group of 12 lean men without objective evidence of untoward side effects. Shapes of the cumulative intake curves under the two conditions were similar, but subjects ate less and stopped eating sooner when receiving octapeptide than when receiving saline. These results are consistent with the hypothesis that cholecystokinin is an endogenous signal for postprandial satiety. The results offer promise for the possible use of the octapeptide as an appetite suppressant.
H R Kissileff; F X Pi-Sunyer; J Thornton; G P Smith
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  34     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-60     Citation Subset:  AIM; IM    
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MeSH Terms
Appetite Depressants*
Appetite Regulation / drug effects*
Cholecystokinin / analogs & derivatives*,  pharmacology,  physiology
Feeding Behavior / drug effects
Satiation / drug effects
Structure-Activity Relationship
Grant Support
Reg. No./Substance:
0/Appetite Depressants; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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