| C-terminal octapeptide of cholecystokinin decreases food intake in man. | |
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MedLine Citation:
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PMID: 6259918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In comparison with a saline infusion, the infusion of the C-terminal octapeptide of cholecystokinin (4 ng/kg/min) decreased food intake by an average of 122 g in a group of 12 lean men without objective evidence of untoward side effects. Shapes of the cumulative intake curves under the two conditions were similar, but subjects ate less and stopped eating sooner when receiving octapeptide than when receiving saline. These results are consistent with the hypothesis that cholecystokinin is an endogenous signal for postprandial satiety. The results offer promise for the possible use of the octapeptide as an appetite suppressant. |
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Authors:
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H R Kissileff; F X Pi-Sunyer; J Thornton; G P Smith |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 34 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-05-28 Completed Date: 1981-05-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 154-60 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Appetite Depressants* Appetite Regulation / drug effects* Cholecystokinin / analogs & derivatives*, pharmacology, physiology Diet* Feeding Behavior / drug effects Humans Male Satiation / drug effects Sincalide Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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AM-17624/AM/NIADDK NIH HHS; MH-00149/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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