Document Detail


The C-terminal Src kinase (Csk) is widely expressed, active in HT-29 cells that contain activated Src, and its expression is downregulated in butyrate-treated SW620 cells.
MedLine Citation:
PMID:  8979366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Csk expression was examined in human glioma, breast and colon cell lines, along with murine tissues. Relative to colon and glioma cell lines, Csk expression was highest in the breast cell lines. Relative to brain tissue, expression was 100-fold higher in the heart, kidney, liver, lung and spleen. Subcellular fractionation and cellular immunostaining indicated that it was localized in the cytosolic fraction. The expression of Csk was downregulated upon chemical-induced differentiation of SW620 human colon cells by treatment with sodium butyrate. Its expression localization and activity relative to Src are discussed.
Authors:
S Li; S Ke; R J Budde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell biology international     Volume:  20     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-05     Completed Date:  1997-02-05     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  723-9     Citation Subset:  IM    
Affiliation:
Department of Neuro-Oncology, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Breast Neoplasms / enzymology,  pathology
Butyric Acid
Butyric Acids / pharmacology*
Cell Differentiation / drug effects
Colonic Neoplasms / enzymology,  pathology
Enzyme Induction / drug effects
Gene Expression Regulation, Neoplastic / drug effects*
Humans
Neoplasm Proteins / biosynthesis*,  genetics
Subcellular Fractions / enzymology
Tumor Cells, Cultured / drug effects
src-Family Kinases / biosynthesis*,  genetics,  metabolism
Grant Support
ID/Acronym/Agency:
CA16672/CA/NCI NIH HHS; CA53617/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Butyric Acids; 0/Neoplasm Proteins; 107-92-6/Butyric Acid; EC 2.7.10.2/CSK tyrosine-protein kinase; EC 2.7.10.2/src-Family Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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