Document Detail

C-reactive protein and vulnerability to mental stress-induced myocardial ischemia.
MedLine Citation:
PMID:  17380191     Owner:  NLM     Status:  MEDLINE    
Myocardial ischemia provoked in the laboratory during mental stress (MSI) in patients with stable coronary artery disease (CAD) predicts subsequent clinical events. The pathophysiology of MSI differs from that of exercise ischemia, and the mechanisms tying MSI to poor prognosis are not known. C-reactive protein (CRP) is a risk marker for cardiovascular events in patients with CAD, but little is known regarding the relationship of CRP to MSI. The purpose of this study was to examine the association of CRP to risk of MSI in CAD patients. Eighty-three patients with stable CAD underwent simultaneous single-photon emission computed tomography (SPECT) imaging with technetium-99m tetrofosmin myocardial perfusion imaging (MPI) and transthoracic echocardiography (TTE), at rest and during MS induced by laboratory mental stress. Serum CRP levels were measured 24 h after MS. MSI was defined by the presence of a new perfusion defect on SPECT and/or new regional wall motion abnormality on TTE during MS. Of the 83 patients, 30 (36%) developed MSI. There was no difference in gender, sex, BMI, histories of diabetes, hypertension, smoking, lipid profile, medications used (including statins, beta-blockers, ACE inhibitors, and aspirin), or hemodynamic response during MS between those with and without MSI. In univariate logistic regression analysis, each unit (1 mg/L) increase in CRP level was associated with 20% higher risk of MSI (OR 1.2, 95% CI 1.01-1.39, P=.04). This relationship remained in multivariate models. These data suggest that levels of CRP may be a risk marker for MSI in patients with CAD.
Rahman Shah; Matthew M Burg; Aseem Vashist; Dorothea Collins; Joyce Liu; Farid Jadbabaie; Brendon Graeber; Christine Earley; Rachel Lampert; Robert Soufer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Molecular medicine (Cambridge, Mass.)     Volume:  12     ISSN:  1076-1551     ISO Abbreviation:  Mol. Med.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2007-03-23     Completed Date:  2007-06-07     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  9501023     Medline TA:  Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
C-Reactive Protein / metabolism*
Coronary Disease / blood*,  psychology,  radionuclide imaging
Heart Rate
Myocardial Ischemia / physiopathology,  psychology*
Organophosphorus Compounds / diagnostic use
Organotechnetium Compounds / diagnostic use
Radiopharmaceuticals / diagnostic use
Stress, Psychological*
Tomography, Emission-Computed, Single-Photon
Grant Support
R01 HL071116-01/HL/NHLBI NIH HHS; R01 HL089314/HL/NHLBI NIH HHS; R01 HL59619-01/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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