| C-reactive protein is a strong predictor for anaemia in renal cell carcinoma: role of IL-6 in overall survival. | |
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MedLine Citation:
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PMID: 21070572 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: • To elucidate the association of progression of advanced renal cell carcinoma with anaemia and investigate factors influencing tumor-associated anaemia. PATIENTS AND METHODS: • We analyzed different clinical variables to study associations with anaemia in 86 metastatic renal cell carcinoma patients. • 45 (52%) of patients had already developed anaemia prior to therapy. RESULTS: • Anaemic patients had an increase in the serum markers C-reactive protein (CRP), IL-6 and erythropoietin (EPO). In addition we observed substantial correlation between IL-6 and CRP serum levels (R = 0.639, P < 0.0001). • Univariate logistic regression analysis revealed that patients with IL-6 >10 pg/mL had a considerable increase in risk for anaemia (odds ratio 3.86, P= 0.003). • In addition, patients with CRP >0.7 mg/dL had a very strong increase in risk for anaemia (OR = 14.08, P < 0.0001). • Stepwise multivariate logistic regression analysis confirmed CRP >0.7 mg/mL as the only independent predictor for anaemia. Cox-regression modeling selected serum IL-6 as the strongest independent prognostic indicator (hazard ratio 3.58, P < 0.0001). CONCLUSION: • Anaemia depends on serum IL-6, which is a strong inductor of CRP and regulator of the iron-transport. Serum IL-6 may be considered as a target to treat cancer-related anaemia. |
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Authors:
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Claudia E Falkensammer; Martin Thurnher; Nicolai Leonhartsberger; Reinhold Ramoner |
Publication Detail:
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Type: Journal Article Date: 2010-11-10 |
Journal Detail:
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Title: BJU international Volume: 107 ISSN: 1464-410X ISO Abbreviation: BJU Int. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886721 Medline TA: BJU Int Country: England |
Other Details:
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Languages: eng Pagination: 1893-8 Citation Subset: IM |
Copyright Information:
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© 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL. |
Affiliation:
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Immunotherapy Unit, Department of Urology, Innsbruck Medical University, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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