Document Detail


C-reactive protein: a serological marker for preterm delivery?
MedLine Citation:
PMID:  12027816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We studied the association between the C-reactive protein level in the maternal serum early in the second trimester with that in preterm delivery. METHODS: The present study is a prospective nested case-control study including 84 singleton, preterm deliveries (cases) and 400 singleton, term deliveries (controls), based at the Odense University Hospital, Denmark. These cases were identified from a cohort of 2846 women, monitored from their first prenatal care visit until their delivery. All the participants were examined at enrollment (median 16.3 weeks of gestation). Conventional statistical methods were used for analyses. RESULTS: We found statistically significant differences in the C-reactive protein levels measured in early pregnancy between the women delivering preterm and those delivering at term. Different statistically significant odds ratios of between 1.7 and 2.0 were calculated, depending on the C-reactive protein level's cut-off value, and ranged from 5.6 mg/l (75th percentile) to 16.4 mg/l (95th percentile). The highest level was achieved at the 85th percentile (7.6 mg/l); odds ratio 2.0 (95%CI, 1.2-3.5). CONCLUSION: A high C-reactive protein level at the beginning of a pregnancy is associated with a nearly twofold increased risk of preterm delivery; however, the clinical value at this point is still limited.
Authors:
Gitte B Hvilsom; Poul Thorsen; Bernard Jeune; Leiv S Bakketeig
Related Documents :
9757986 - Effects of fetal sex and race on risk of very preterm birth in twins.
23033876 - Formation of high-molecular weight angiotensinogen during pregnancy is a result of comp...
7872326 - Pregnancy and kidney transplantation: experience in a developing country.
3748496 - Pneumococcal polysaccharide antibody levels in patients with term and preterm pregnancies.
20003846 - Effects of gamete source and culture conditions on the competence of in vitro-produced ...
16799076 - Small airway function improvement after smoking cessation in smokers without airway obs...
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  81     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-24     Completed Date:  2002-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  424-9     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense. Gitte@hvilsom.dk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
C-Reactive Protein / metabolism*
Case-Control Studies
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Obstetric Labor, Premature / blood*,  diagnosis*
Odds Ratio
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, Second
Prenatal Diagnosis / standards*
Prospective Studies
ROC Curve
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Accuracy of fetal pulse oximetry.
Next Document:  Possible role of the long dorsal sacroiliac ligament in women with peripartum pelvic pain.