Document Detail


C-reactive protein is related to impaired oxygenation in patients with acute aortic dissection.
MedLine Citation:
PMID:  16272770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired oxygenation sometimes occurs in patients with acute aortic dissection, however, the mechanism has not been fully investigated. We hypothesized that impaired oxygenation is related to inflammation secondary due to aortic dissection. Patients with acute aortic dissection who had received 14 days of conservative treatment were retrospectively examined. Patients who had undergone surgery or died within 14 days were excluded. Patients who had evidence of having pneumonia or pulmonary congestion during this period were also excluded. Twenty-six patients were divided into a preserved oxygenation group (minimum oxygenation index > or = 200, n = 13) and an impaired oxygenation group (minimum oxygenation index < 200, n = 13). Maximum serum C-reactive protein (max CRP) and other factors (age, gender, hypertension, diabetes mellitus, smoking, hyperlipidemia, Stanford type, thrombosed false lumen, pleural effusion, atelectasis, use of intravenous vasodilators) for the two groups were compared. Max CRP was the only predictor for impaired oxygenation as calculated by single/multiple logistic regression analysis. Max CRP was significantly higher in the impaired oxygenation group (20.1 +/- 2.1 mg/dL) than in the preserved oxygenation group (10.5 +/- 1.4 mg/dL, P < 0.05). These results suggest that impaired oxygenation is related to inflammation, which is secondary due to acute aortic dissection.
Authors:
Kimiaki Komukai; Takahiro Shibata; Seibu Mochizuki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  46     ISSN:  1349-2365     ISO Abbreviation:  -     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-11-07     Completed Date:  2006-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  795-9     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Nishishinbashi, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aneurysm, Dissecting / complications,  metabolism*
Anoxia / blood,  etiology*
Aortic Aneurysm / complications,  metabolism*
Biological Markers / blood
C-Reactive Protein / analysis*
Female
Humans
Inflammation / blood
Male
Middle Aged
Oxygen Consumption
Pleural Effusion / etiology
Retrospective Studies
Chemical
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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