Document Detail


C-reactive protein predicts non-target lesion revascularization and cardiac events following percutaneous coronary intervention in patients with angina pectoris.
MedLine Citation:
PMID:  19477381     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: C-reactive protein (CRP) plays a pivotal role in the pathogenesis of atherosclerosis progression. We hypothesized that CRP might be related to progression of non-target lesion and prognosis in patients with angina pectoris.
METHODS AND RESULTS: We enrolled 111 patients with angina pectoris treated with coronary stenting. CRP was measured before coronary stenting. Patients were grouped according to the CRP value, high CRP group (n=56, ≥ 0.12 mg/dl) and low CRP group (n=55, <0.12 mg/dl). Kaplan-Meier analysis showed that non-target lesion revascularization (TLR) free survival was significantly lower in the high CRP group than in the low CRP group (log-rank, p=0.004). Moreover, cardiac event (death, myocardial infarction, TLR, and non-TLR) free survival was also significantly lower in the high CRP group than in the low CRP group (p=0.004). By univariate and multivariate analysis, CRP was the only independent predictor of non-TLR (odds ratio, 1.26; p<0.001 [95% confidence interval (CI) 0.98-1.64]). Also, CRP was a predictor of the cardiac events (odds ratio, 1.32; p=0.04 [95% CI 1.02-1.72]).
CONCLUSIONS: CRP was a predictor of non-TLR and cardiac events following stenting in patients with angina pectoris.
Authors:
Koichiro Imai; Hiroyuki Okura; Teruyoshi Kume; Ryotaro Yamada; Yoshinori Miyamoto; Takahiro Kawamoto; Yoji Neishi; Nozomi Watanabe; Eiji Toyota; Kiyoshi Yoshida
Publication Detail:
Type:  Journal Article     Date:  2009-02-20
Journal Detail:
Title:  Journal of cardiology     Volume:  53     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  388-95     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
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