Document Detail

C-reactive protein predicts future arterial and cardiovascular events in patients with symptomatic peripheral arterial disease.
MedLine Citation:
PMID:  18458051     Owner:  NLM     Status:  MEDLINE    
High-sensitivity C-reactive protein is associated with increased risk of cardiovascular events. Consequently, the predictive value of this protein in patients with symptomatic peripheral arterial disease was examined. In all, 452 patients with symptomatic peripheral arterial disease had high-sensitivity C-reactive protein measured at baseline (mean follow-up = 2.1 +/- 1.4 years). Events were defined as primary (death, amputation, or peripheral revascularization) or secondary (lower limb thrombosis, myocardial infarction, or stroke).The level of high-sensitivity C-reactive protein was significantly higher among those dying (P = .04), those who needed amputation (P = .01), and those developing an overall secondary endpoint (P = .02). By receiver-operating characteristic curve analysis, the optimal cutoff point was constantly approximately 10 to 20 mg/L with a sensitivity and specificity of 56% to 63% and 54% to 56%, respectively. Baseline levels of high-sensitivity C-reactive protein are associated with future arterial events in symptomatic peripheral arterial disease patients but cannot stand alone as a predictive tool.
Annette L Hogh; Jette Joensen; Jes S Lindholt; Martin R Jacobsen; Lars Ostergaard
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2008-05-05
Journal Detail:
Title:  Vascular and endovascular surgery     Volume:  42     ISSN:  1538-5744     ISO Abbreviation:  Vasc Endovascular Surg     Publication Date:    2008 Aug-Sep
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-12-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136421     Medline TA:  Vasc Endovascular Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
Department of Vascular Surgery, Vascular Research Unit, Viborg Hospital, Viborg, Denmark.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis*
Cardiovascular Diseases / blood,  etiology*,  mortality,  therapy
Disease Progression
Middle Aged
Peripheral Vascular Diseases / blood*,  complications,  mortality,  therapy
Predictive Value of Tests
Prospective Studies
ROC Curve
Reproducibility of Results
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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