| C-reactive protein and n-3 fatty acids in patients with a previous myocardial infarction: a placebo-controlled randomized study. | |
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MedLine Citation:
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PMID: 17676423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dietary intake of the marine long-chain n-3 polyunsaturated fatty acids (PUFA) may reduce mortality after a myocardial infarction (MI). This may partly be attributed to their anti-inflammatory properties. AIM OF THE STUDY: To investigate the effect of n-3 PUFA on C-reactive protein (CRP) in patients with a previous MI. METHODS: In a double-blind design, forty-one patients (mean age 63 +/- 7 years) were randomized to receive daily supplements with 5.2 g of n-3 PUFA or olive oil (control). Serum CRP was measured with a highly sensitive assay (hs-CRP) before and after 12 weeks supplements. Compliance was monitored by measuring the incorporation of n-3 PUFA into platelets. RESULTS: The content of n-3 PUFA in platelets increased significantly in the n-3 PUFA supplemented group, whereas no changes were seen in controls. There was a minor increase in hs-CRP in the n-3 PUFA group (2.46 vs. 2.70 mg/l) and a small decrease in hs-CRP in the control group (2.52 vs. 1.67 mg/l). The changes, however, were not statistically significant (P = 0.30 and 0.43, respectively). CONCLUSION: Supplementation with 5.2 g of n-3 PUFA for 12 weeks had no hs-CRP lowering effect in patients with a previous MI. |
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Authors:
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Trine Madsen; Jeppe H Christensen; Erik B Schmidt |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2007-08-04 |
Journal Detail:
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Title: European journal of nutrition Volume: 46 ISSN: 1436-6207 ISO Abbreviation: Eur J Nutr Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-12-17 Completed Date: 2008-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: Germany |
Other Details:
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Languages: eng Pagination: 428-30 Citation Subset: IM |
Affiliation:
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Dept. of Cardiology, Aalborg Hospital, PO Box 365, 9100 Aalborg, Denmark. tmadsen@dadlnet.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Platelets / chemistry* C-Reactive Protein / analysis*, drug effects, metabolism Dietary Fats, Unsaturated / administration & dosage*, metabolism Dietary Supplements Double-Blind Method Fatty Acids, Omega-3 / administration & dosage*, metabolism Female Humans Male Middle Aged Myocardial Infarction / blood, drug therapy* Patient Compliance Plant Oils Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 0/Plant Oils; 8001-25-0/olive oil; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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