| C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study. | |
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MedLine Citation:
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PMID: 15262834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. METHODS AND RESULTS: We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. MetS (> or =3 of 5 traits) was present in 24% of subjects; mean age-adjusted CRP levels for those with 0, 1, 2, 3, 4, or 5 MetS traits were 2.2, 3.5, 4.2, 6.0, or 6.6 mg/L, respectively (P trend <0.0001). In persons with MetS, age-adjusted CRP levels were higher in women than men (7.8 versus 4.6 mg/L; P<0.0001). MetS and baseline CRP were individually related to CVD events (for MetS: age-sex-adjusted hazard ratio [HR], 2.1; 95% CI, 1.5 to 2.8; for highest versus lowest CRP quartile: HR, 2.2; 95% CI, 1.4 to 3.5). Greater risk of CVD persisted for MetS and CRP even after adjustment in a model including age, sex, MetS (HR, 1.8; 95% CI, 1.4 to 2.5), and CRP (HR, 1.9; 95% CI, 1.2 to 2.9). The c-statistic associated with the age- and sex-adjusted model including CRP was 0.72; including MetS, 0.74; and including CRP and MetS, 0.74. CONCLUSIONS: Elevated CRP levels are related to insulin resistance and the presence of the MetS, especially in women. Although discrimination of subjects at risk of CVD events using both MetS and CRP is not better than using either phenotype alone, both CRP and MetS are independent predictors of new CVD events. |
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Authors:
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Martin K Rutter; James B Meigs; Lisa M Sullivan; Ralph B D'Agostino; Peter W F Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2004-07-19 |
Journal Detail:
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Title: Circulation Volume: 110 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-27 Completed Date: 2005-01-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 380-5 Citation Subset: AIM; IM |
Affiliation:
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Countess of Chester Hospital, Chester, UK. Martin.Rutter@coch.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over C-Reactive Protein / analysis* Cardiovascular Diseases / blood*, epidemiology Cohort Studies Cross-Sectional Studies Female Follow-Up Studies Humans Inflammation / blood Insulin Resistance Male Metabolic Syndrome X / blood*, epidemiology Middle Aged Predictive Value of Tests Risk Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-25195/HC/NHLBI NIH HHS; R01-HL-073272-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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