| C-reactive protein, marker for evaluation of systemic inflammatory response in preeclampsia. | |
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MedLine Citation:
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PMID: 20209780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Determination by a high sensitivity technique of serum C-reactive protein (CRP), a sensitive marker of inflammation in women with preeclampsia compared to normal pregnancy and investigation of the relationship between CRP and the severity of the preeclamptic syndrome. MATERIAL AND METHOD: The study included 40 women with preeclampsia and 40 control subjects with normal pregnancies in the last trimester of pregnancy. The serum CRP concentration was determined using the universal high sensitivity immunoturbidimetric assay. RESULTS: The serum CRP concentration was significantly higher (p < 0.001) in preclampsia (5.69 +/- 1.8 mg/L) compared to normal pregnancy (2.89 +/- 1.2 mg/L). In women with preeclampsia, CRP correlated positively and significantly with diastolic blood pressure, proteinuria and uric acid levels. Maternal CRP values also correlated negatively and significantly with fetal weight at birth. CONCLUSIONS: Our results demonstrate that serum CRP is increased in preeclampsia and represents a marker of the severity of the preeclamptic syndrome and of fetal weight at birth. Taking into consideration these observations and the fact that CRP testing is rapid and relatively inexpensive, we recommend the use of this acute phase reagent in clinical practice, in all women with preeclampsia in order to establish the prognosis of the disease. |
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Authors:
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D Mihu; N Costin; Carmen Mihaela Mihu; Ligia Daniela Blaga; Raluca Bogdana Pop |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i Volume: 112 ISSN: 0048-7848 ISO Abbreviation: Rev Med Chir Soc Med Nat Iasi Publication Date: 2008 Oct-Dec |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-05-10 Revised Date: 2011-01-13 |
Medline Journal Info:
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Nlm Unique ID: 0413735 Medline TA: Rev Med Chir Soc Med Nat Iasi Country: Romania |
Other Details:
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Languages: eng Pagination: 1019-25 Citation Subset: IM |
Affiliation:
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Dominic Stanca Clinic of Obstetrics and Gynecology, School of Medicine, Haţieganu University of Medecine and Pharmacy Cluj-Napoca. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Body Mass Index C-Reactive Protein / metabolism* Case-Control Studies Female Fetal Weight* Humans Pre-Eclampsia / blood*, diagnosis Predictive Value of Tests Pregnancy Pregnancy Trimester, Third Risk Factors Sensitivity and Specificity Severity of Illness Index Systemic Inflammatory Response Syndrome / blood*, diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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