Document Detail

C-reactive protein, marker for evaluation of systemic inflammatory response in preeclampsia.
MedLine Citation:
PMID:  20209780     Owner:  NLM     Status:  MEDLINE    
AIM: Determination by a high sensitivity technique of serum C-reactive protein (CRP), a sensitive marker of inflammation in women with preeclampsia compared to normal pregnancy and investigation of the relationship between CRP and the severity of the preeclamptic syndrome.
MATERIAL AND METHOD: The study included 40 women with preeclampsia and 40 control subjects with normal pregnancies in the last trimester of pregnancy. The serum CRP concentration was determined using the universal high sensitivity immunoturbidimetric assay.
RESULTS: The serum CRP concentration was significantly higher (p < 0.001) in preclampsia (5.69 +/- 1.8 mg/L) compared to normal pregnancy (2.89 +/- 1.2 mg/L). In women with preeclampsia, CRP correlated positively and significantly with diastolic blood pressure, proteinuria and uric acid levels. Maternal CRP values also correlated negatively and significantly with fetal weight at birth.
CONCLUSIONS: Our results demonstrate that serum CRP is increased in preeclampsia and represents a marker of the severity of the preeclamptic syndrome and of fetal weight at birth. Taking into consideration these observations and the fact that CRP testing is rapid and relatively inexpensive, we recommend the use of this acute phase reagent in clinical practice, in all women with preeclampsia in order to establish the prognosis of the disease.
D Mihu; N Costin; Carmen Mihaela Mihu; Ligia Daniela Blaga; Raluca Bogdana Pop
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i     Volume:  112     ISSN:  0048-7848     ISO Abbreviation:  Rev Med Chir Soc Med Nat Iasi     Publication Date:    2008 Oct-Dec
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-05-10     Revised Date:  2011-01-13    
Medline Journal Info:
Nlm Unique ID:  0413735     Medline TA:  Rev Med Chir Soc Med Nat Iasi     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  1019-25     Citation Subset:  IM    
Dominic Stanca Clinic of Obstetrics and Gynecology, School of Medicine, Haţieganu University of Medecine and Pharmacy Cluj-Napoca.
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MeSH Terms
Biological Markers / blood
Body Mass Index
C-Reactive Protein / metabolism*
Case-Control Studies
Fetal Weight*
Pre-Eclampsia / blood*,  diagnosis
Predictive Value of Tests
Pregnancy Trimester, Third
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
Systemic Inflammatory Response Syndrome / blood*,  diagnosis*
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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