| C-reactive protein levels and survival in patients with moderate to very severe COPD. | |
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MedLine Citation:
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PMID: 18339787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum levels of C-reactive protein (CRP) are increased in patients with COPD and correlate modestly with variables predictive of outcomes. In epidemiologic studies, CRP level is associated with all-cause mortality in patients with mild-to-moderate disease. OBJECTIVE: To determine if CRP levels are associated with survival in patients with moderate to very severe COPD in comparison with other well-known prognostic parameters of the disease. METHODS: In 218 stable patients with COPD, we measured baseline serum CRP level, BODE (body mass index, obstruction, dyspnea, and exercise capacity) index and its components, arterial oxygenation (Pao(2)), inspiratory capacity (IC) to total lung capacity (TLC) ratio, and Charlson comorbidity score. We followed up the patients over time and evaluated the strength of the association between the variables and all-cause mortality. RESULTS: During the follow-up time (median, 36 months; 25th to 75th percentiles, 24 to 50 months), 54 patients (25%) died. CRP levels were similar between survivors and the deceased (median, 3.8 mg/L; 95% confidence interval, 1.9 to 8.1; vs median, 4.5 mg/L; 95% confidence interval, 2.1 to 11.5; p = 0.22) and was not significantly associated with survival. CONCLUSIONS: In this population of patients with clinically moderate to very severe COPD, the level of CRP level was not associated with survival compared with other prognostic clinical tools such as the BODE index, modified Medical Research Council scale, 6-min walk distance, percentage of predicted FEV(1), IC/TLC ratio < 0.25, and Pao(2). Other long-term studies of well-characterized patients with COPD could help determine the exact role of CRP levels as a biomarker in patients with clinical COPD. |
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Authors:
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Juan P de Torres; Victor Pinto-Plata; Ciro Casanova; Hanna Mullerova; Elizabeth Córdoba-Lanús; Mercedes Muros de Fuentes; Armando Aguirre-Jaime; Bartolome R Celli |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2008-03-13 |
Journal Detail:
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Title: Chest Volume: 133 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-24 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1336-43 Citation Subset: AIM; IM |
Affiliation:
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Respiratory Research Unit, Hospital Ntra Sra de Candelaria, Canary Islands, Tenerife, Spain. jupa65@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Body Mass Index C-Reactive Protein / metabolism* Female Follow-Up Studies Humans Male Middle Aged Predictive Value of Tests Prognosis Prospective Studies Pulmonary Disease, Chronic Obstructive / blood*, classification, mortality Severity of Illness Index Survival Analysis |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Chest. 2008 Jun;133(6):1296-8
[PMID:
18574284
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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