Document Detail

C-reactive protein levels in African Americans: a diet and lifestyle randomized community trial.
MedLine Citation:
PMID:  24050419     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic inflammation is linked to poor lifestyle behaviors and a variety of chronic diseases that are prevalent among African Americans, especially in the southeastern U.S.
PURPOSE: The goal of the study was to test the effect of a community-based diet, physical activity, and stress reduction intervention conducted in 2009-2012 on reducing serum C-reactive protein (CRP) in overweight and obese African-American adults.
METHODS: An RCT intervention was designed jointly by members of African-American churches and academic researchers. In late 2012, regression (i.e., mixed) models were fit that included both intention-to-treat and post hoc analyses conducted to identify important predictors of intervention success. Outcomes were assessed at 3 months and 1 year.
RESULTS: At baseline, the 159 individuals who were recruited in 13 churches and had evaluable outcome data were, on average, obese (BMI=33.1 [±7.1]) and had a mean CRP level of 3.7 (±3.9) mg/L. Reductions were observed in waist-to-hip ratio at 3 months (2%, p=0.03) and 1 year (5%, p<0.01). In female participants attending ≥60% of intervention classes, there was a significant decrease in CRP at 3 months of 0.8 mg/L (p=0.05), but no change after 1 year. No differences were noted in BMI or interleukin-6.
CONCLUSIONS: In overweight/obese, but otherwise "healthy," African-American church members with very high baseline CRP levels, this intervention produced significant reductions in CRP at 3 and 12 months, and in waist-to-hip ratio, which is an important anthropometric predictor of overall risk of inflammation and downstream health effects.
TRIAL REGISTRATION: This study is registered at NCT01760902.
James R Hébert; Michael Wirth; Lisa Davis; Briana Davis; Brook E Harmon; Thomas G Hurley; Ruby Drayton; E Angela Murphy; Nitin Shivappa; Sara Wilcox; Swann A Adams; Heather M Brandt; Christine E Blake; Cheryl A Armstead; Susan E Steck; Steven N Blair
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of preventive medicine     Volume:  45     ISSN:  1873-2607     ISO Abbreviation:  Am J Prev Med     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-20     Completed Date:  2014-05-05     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  8704773     Medline TA:  Am J Prev Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  430-40     Citation Subset:  IM    
Copyright Information:
© 2013 American Journal of Preventive Medicine.
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MeSH Terms
African Americans / statistics & numerical data*
Body Mass Index
C-Reactive Protein / analysis*
Diet / ethnology*
Health Behavior / ethnology
Health Promotion / organization & administration*
Life Style / ethnology*
Middle Aged
Overweight / ethnology
Socioeconomic Factors
Stress, Psychological / ethnology
Grant Support
K05 CA136975/CA/NCI NIH HHS; K05 CA136975/CA/NCI NIH HHS; R24 MD002769/MD/NIMHD NIH HHS; R24 MD002769/MD/NIMHD NIH HHS; R25 CA090956/CA/NCI NIH HHS; R25 CA090956/CA/NCI NIH HHS
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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