| C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients. | |
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MedLine Citation:
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PMID: 21238518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD and hs-CRP are independent of body mass index (BMI) in its broad range among obese patients. METHODS: A total of 627 obese adults (80% females), representing three cohorts from France and Belgium, had information on liver histology obtained from liver biopsies and measures of hs-CRP and BMI. We investigated whether the different features of NAFLD and BMI were associated with hs-CRP, with and without mutual adjustments using linear regression. RESULTS: BMI and hs-CRP were strongly associated. Per every 10% increase in BMI the hs-CRP level increased by 19-20% (p<0.001), and adjustment for NAFLD-stage (including no-NAFLD) did not influence the association. We found no BMI-independent association between NASH and hs-CRP. However, a positive association between degree of steatosis and hs-CRP was observed (p<0.05) and this effect remained significant after adjusting for BMI, lobular inflammation, hepatocyte ballooning, and fibrosis. We found no significant associations between the other features of NAFLD and hs-CRP. CONCLUSIONS: This study indicates that it is the accumulation of fat -both in the adipose tissue and in liver steatosis- that leads to increased hs-CRP levels among obese patients. Thus, hs-CRP may be a marker of steatosis, but not of severity of NAFLD, in obese patients. |
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Authors:
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Esther Zimmermann; Rodolphe Anty; Joan Tordjman; An Verrijken; Philippe Gual; Albert Tran; Antonio Iannelli; Jean Gugenheim; Pierre Bedossa; Sven Francque; Yannick Le Marchand-Brustel; Karine Clement; Luc Van Gaal; Thorkild I A Sørensen; Tine Jess |
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Publication Detail:
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Type: Journal Article Date: 2011-01-14 |
Journal Detail:
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Title: Journal of hepatology Volume: 55 ISSN: 1600-0641 ISO Abbreviation: J. Hepatol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-19 Completed Date: 2012-01-23 Revised Date: 2012-08-24 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 660-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark. ez@ipm.regionh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity Adolescent Adult Aged Biological Markers / metabolism Body Mass Index* C-Reactive Protein / metabolism* Fatty Liver / complications, metabolism*, pathology* Female Humans Linear Models Male Middle Aged Obesity / complications, metabolism* Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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J Hepatol. 2012 Feb;56(2):507-8; author reply 508-10
[PMID:
21888877
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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