| C-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbits. | |
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MedLine Citation:
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PMID: 22374730 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression of atherosclerosis. To examine this hypothesis, we investigated different types of atherosclerotic lesions of rabbits fed with a cholesterol-rich diet for 6, 12, 16, and 28 weeks and examined their relationship with CRP. We measured the aortic atherosclerotic area, macrophages, and smooth muscle cells along with CRP contents in the lesions. Atherosclerotic lesions of aortas began to form at 6 weeks and were characterized by accumulation of macrophages in the intima, and lesions became more fibrotic in the advanced stage. Both plasma CRP levels and the lesional CRP contents were associated with the lesion size. Our results suggest that plasma CRP, as well as lesional CRP, associated with the formation and progression of atherosclerotic lesions. |
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Authors:
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Q Yu; Y Li; Y Wang; S Zhao; P Yang; Y Chen; J Fan; E Liu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histology and histopathology Volume: 27 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-02-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 529-35 Citation Subset: IM |
Affiliation:
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Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University School of Medicine, Xi'an, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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