Document Detail

C-reactive protein level in severe stenosis of cerebral arteries.
MedLine Citation:
PMID:  17406113     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: C-reactive protein (CRP) as a non-specific inflammatory biomarker has been demonstrated to actively contribute to all stages of atherogenesis. The aim of this study was to investigate the relation between CRP concentrations and the severity of stenosis of cerebral arteries. METHODS: Lipid parameters and CRP levels were measured in the sera of 119 patients with stenosis of the extracranial cerebral arteries established by angiography and compared with the control group, with a normal appearance of the cerebral arteries on ultrasound examination. CRP concentrations were determined by a high-sensitivity assay. RESULTS: CRP concentrations showed a statistically significant difference in the group of patients with cerebrovascular stenosis of more than 70% compared to the control group (median value 3.4 vs. 1.5 mg/l in the control group, p < 0.05). At logistic regression analysis, CRP was significantly associated with stenosis of more than 70%. CONCLUSION: In addition to traditional biochemical risk markers, an elevated CRP level measured on automated analysers using a high-sensitivity assay may be useful in the detection of patients with severe stenosis of the cerebral arteries.
Zlata Flegar-Mestrić; Danijela Vrhovski-Hebrang; Vlatka Preden-Kereković; Sonja Perkov; Andrija Hebrang; Ante Grga; Dragutin Janus; V Vidjak
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-02
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  23     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  430-4     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Institute of Clinical Chemistry, Department of Surgery, Merkur University Hospital, Zagreb, Croatia.
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MeSH Terms
Aged, 80 and over
Angiography, Digital Subtraction
Biological Markers / blood
C-Reactive Protein / metabolism*
Cerebral Arteries / pathology*
Constriction, Pathologic / blood
Immunoassay / methods
Intracranial Arteriosclerosis / blood*,  diagnosis*,  pathology
Lipids / blood
Logistic Models
Middle Aged
Nephelometry and Turbidimetry
Predictive Value of Tests
Sensitivity and Specificity
Severity of Illness Index
Ultrasonography, Doppler, Duplex
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 9007-41-4/C-Reactive Protein

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