Document Detail

C-reactive protein and intercellular adhesion molecule-1 are stronger predictors of oxidant stress than blood pressure in established hypertension.
MedLine Citation:
PMID:  17211250     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oxidant stress is implicated in the pathogenesis of atherosclerosis in cardiovascular diseases. Our aim was to test oxidative stress, as 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), and its relationship with inflammation markers C-reactive protein (CRP) and tumour necrosis factor-alpha (TNFalpha), and endothelial activation assayed as soluble intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in essential hypertension. METHODS: In 216 essential hypertensive patients and 55 healthy control individuals, plasma levels of high-sensitivity CRP and TNFalpha, 8-iso-PGF2alpha, ICAM-1 and VCAM-1 were measured in basal conditions. Moreover, basal and 24-h ambulatory blood pressure monitoring measurements were obtained. RESULTS: Essential hypertensive patients showed higher levels of 8-iso-PGF2alpha (P < 0.0001), high-sensitivity CRP, TNFalpha, ICAM-1 and VCAM-1 (P < 0.001, respectively) than control individuals. In control individuals, 8-iso-PGF2alpha correlated only with high-sensitivity CRP (P < 0.001). In essential hypertensive patients, 8-iso-PGF2alpha correlated with high-sensitivity CRP (P < 0.000001), TNFalpha (P < 0.0001), ICAM-1 (P < 0.000001), VCAM-1 (P < 0.0001) and blood pressure. The multiple regression analysis considering 8-iso-PGF2alpha as the dependent variable showed that in essential hypertensive patients the independent predictors of 8-iso-PGF2alpha were ICAM-1, high-sensitivity CRP (P < 0.00001, respectively), and TNFalpha (P = 0.028). CONCLUSION: Our findings demonstrate that oxidant stress is increased in essential hypertension, and relates to inflammation and endothelial activation. Factors other than blood pressure are stronger predictors of oxidant stress.
Santina Cottone; Giuseppe Mulè; Emilio Nardi; Anna Vadalà; Maria C Lorito; Marco Guarneri; Rosalia Arsena; Alessandro Palermo; Giovanni Cerasola
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  25     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  IM    
Cattedra di Medicina Interna, Divisione di Medicina Interna, Nefrologia ed Ipertensione Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Università di Palermo, Italy.
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MeSH Terms
Biological Markers / blood
Blood Pressure
Blood Pressure Monitoring, Ambulatory
C-Reactive Protein / analysis*
Case-Control Studies
Dinoprost / analogs & derivatives,  blood
Hypertension / blood*,  diagnosis
Intercellular Adhesion Molecule-1 / blood*
Middle Aged
Oxidative Stress / physiology*
Predictive Value of Tests
Tumor Necrosis Factor-alpha / blood
Vascular Cell Adhesion Molecule-1 / blood
Reg. No./Substance:
0/Biological Markers; 0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost; 9007-41-4/C-Reactive Protein

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