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C-reactive protein in relation to early atherosclerosis and periodontitis.
MedLine Citation:
PMID:  21136129     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Periodontitis may affect atherosclerosis via the chronic inflammation. We investigated high-sensitivity C-reactive protein (hsCRP) in relation to early vascular atherosclerotic changes in non-symptomatic subjects with and without long-term periodontitis. Carotid ultrasonography with calculation of common carotid artery intima-media area (cIMA) was performed, and hsCRP and atherosclerosis risk factors were analysed in randomly chosen 93 patients with periodontitis and 41 controls. The relationship between hsCRP, cIMA and atherosclerosis risk factors was evaluated with multiple logistic regression analysis. Women displayed lower hsCRP (p < 0.05) and higher serum HDL (p < 0.001) than men. In all patients with periodontitis, cIMA values were higher than in controls. Periodontitis appeared to be a major predictor for increased cIMA (odds ratio, 3.82; 95% confidence interval, 1.19-12.26). Neither of these factors was significantly associated with hsCRP which thus appeared not sensitive enough to be a marker for periodontitis or atherosclerosis. Hence, irrespective of low hsCRP levels, periodontitis appeared to increase the risk for atherosclerosis.
Authors:
Maha Yakob; Jukka H Meurman; Tomas Jogestrand; Jacek Nowak; Per-Östen Söder; Birgitta Söder
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Publication Detail:
Type:  Journal Article     Date:  2010-12-07
Journal Detail:
Title:  Clinical oral investigations     Volume:  16     ISSN:  1436-3771     ISO Abbreviation:  Clin Oral Investig     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707115     Medline TA:  Clin Oral Investig     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  D    
Affiliation:
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Box 4064, 141 04, Huddinge, Sweden.
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