| C-reactive protein and hormones but not IL-6 are associated to body mass index in first trimester of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20976603 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate if body mass index (BMI) is related to inflammatory markers and hormones in early pregnancy. METHODS: A prospective study with 190 pregnant women evaluated at 10 weeks when leptin, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Median and inter-quartile values of hormones and inflammatory markers are presented according to BMI quintiles. Spearman correlations and Kruskal-Wallis analysis of variance were implemented followed by Mann-Whitney post hoc pair-wise tests. RESULTS: Leptin (P < 0.001), insulin (P = 0.005), HOMA-IR (P = 0.015), and CRP (P = 0.026) assumed higher and significantly median values as BMI quintiles increases, but no differences were observed for IL-6 (P = 0.859). Pair-wise comparisons among quintiles (Q) of BMI were significant for leptin (Q1 × Q3, Q1 × Q4, Q1 × Q5, Q2 × Q4, Q2 × Q5, Q3 × Q5), insulin (Q1 × Q5, Q2 × Q5, Q3 × Q5, Q4 × Q5) and for CRP (Q1 × Q4, Q1 × Q5, Q2 × Q5). Spearman correlation coefficients between BMI showed significant results for leptin (r (s) = 0.58, P < 0.001), insulin (r (s) = 0.19, P = 0.018), HOMA-IR (r (s) = 0.22, P = 0.007), CRP (r (s) = 0.26, P < 0.001), but not for IL-6 (r (s) = -0.06, P = 0.526). Median (mg/L) values of CRP were higher in overweight (35.26) than in normal weight women (21.28, P = 0.051). CONCLUSIONS: The present investigation provides evidences on the positive relationship between BMI, leptin, insulin, HOMA-IR and CRP in early pregnancy. CRP but not IL-6 demonstrated a strong relation with overweight in pregnant women, as early as the tenth week. |
| | |
Authors:
|
Gilberto Kac; Juliana Dos Santos Vaz; Michael Maia Schlüssel; Anibal Sanchez Moura |
Related Documents
:
|
18547343 - Effect of metformin, orlistat and pioglitazone treatment on mean insulin resistance and... 15620433 - Predictive clinical parameters for therapeutic efficacy of rosiglitazone in korean type... 123713 - Bronchoconstrictor effects of a deep inspiration in patients with asthma. |
Publication Detail:
|
Type: Journal Article Date: 2010-10-26 |
Journal Detail:
|
Title: Archives of gynecology and obstetrics Volume: 284 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
|
Languages: eng Pagination: 567-73 Citation Subset: IM |
Affiliation:
|
Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, kacetal@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epithelial remodeling and claudin mRNA abundance in the gill and kidney of puffer fish (Tetraodon bi...
Next Document: The development and general morphology of the telencephalon of actinopterygian fishes: synopsis, doc...