Document Detail

C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity.
MedLine Citation:
PMID:  16546475     Owner:  NLM     Status:  MEDLINE    
An etiologic role for chronic inflammation in the development of insulin resistance has been hypothesized. We determined whether the -732A/G and +219G/A C-reactive protein (CRP) gene variants affect insulin and glucose measures and whether these variants affect training-related changes in insulin sensitivity and glucose measures. Men and women 50 to 75 years old (n = 61) underwent baseline testing that included glucose tolerance, maximal oxygen consumption, body composition, CRP levels, and genotyping assessments. Tests were repeated after 24 weeks of aerobic exercise training. In bivariate analyses, CRP -732A/G G allele carriers had significantly lower baseline postprandial plasma glucose and after-training CRP levels. After exercise training, the -732A/G G allele carriers had approximately 28% increase in insulin sensitivity index (ISI) and approximately 26% reduction in insulin area under the curve (AUC), compared with the approximately 7% increase in ISI and approximately 15% reduction in insulin AUC in the A allele homozygotes (P = .03). The significant enhancement of ISI in -732A/G G allele carriers remained evident in analyses limited to those with normal glucose tolerance. Multivariate analyses adjusted for demographic and biologic variables confirmed the significant enhancement of training-induced improvement in ISI by the CRP gene variant. In addition, the CRP -732A/G and +219G/A haplotype significantly associated with training-induced improvements in ISI and insulin AUC in separate multivariate models. In conclusion, the CRP -732A/G variant modulates exercise training-related improvements in ISI and glucose AUC, and the haplotype of the CRP -732A/G and +219G/A variants significantly affected training-induced changes in ISI and insulin AUC.
Thomas O Obisesan; Christiaan Leeuwenburgh; Robert E Ferrell; Dana A Phares; Jennifer A McKenzie; Steven J Prior; James M Hagberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  55     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-05-02     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  453-60     Citation Subset:  IM    
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA.
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MeSH Terms
Area Under Curve
Blood Glucose / analysis
C-Reactive Protein / genetics*,  metabolism
Gene Frequency
Genetic Variation
Insulin / blood
Insulin Resistance*
Middle Aged
Multivariate Analysis
Physical Education and Training*
Grant Support
AG 00980/AG/NIA NIH HHS; AG 15389/AG/NIA NIH HHS; AG 17474/AG/NIA NIH HHS; K23 AG000980/AG/NIA NIH HHS; K23 AG000980-01A1/AG/NIA NIH HHS; K23 AG000980-02/AG/NIA NIH HHS; K23 AG000980-03/AG/NIA NIH HHS; K23 AG000980-04/AG/NIA NIH HHS; K23 AG000980-05/AG/NIA NIH HHS; RR 10284/RR/NCRR NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; 9007-41-4/C-Reactive Protein

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