Document Detail

C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy.
MedLine Citation:
PMID:  14661006     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Markers of systemic inflammation including C-reactive protein (CRP) appear to predict morbidity and mortality in various clinical conditions. The presence of systemic inflammation and its impact on the procedural success of percutaneous balloon mitral valve commissurotomy (PBMC) in patients with rheumatic mitral stenosis has not been previously demonstrated. METHODS: Measurements of CRP with a high-sensitivity assay were performed at the time of PBMC or during post-procedural follow-up in 119 patients with mitral stenosis of rheumatic morphology. Patients were questioned to exclude confounders of CRP elevation and categorized into undetectable (< or =0.10 mg/L) and detectable (>0.10 mg/L) CRP levels. Detectable levels were further classified into assay range (>0.10 and < or =6.0 mg/L) and elevated (>6.0 mg/L). RESULTS: CRP was detectable in 76% of patients and elevated (>6.0 mg/L) in 36% of patients studied. Procedural success occurred in 89% of patients with undetectable CRP, as compared with only 67% in patients with detectable CRP (P =.028). This effect remained after controlling for age and valve score (previously described predictors of PBMC success). CONCLUSIONS: Systemic inflammation is common in patients with rheumatic mitral valve stenosis, and the relationship between procedural success and CRP suggests persistent inflammation may affect the results of PBMC.
Richard A Krasuski; Anneke Bush; Joseph E Kay; Charles E Mayes; Andrew Wang; Judy Fleming; Cynthia Pierce; Katherine B Kisslo; J Kevin Harrison; Thomas M Bashore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  146     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-08     Completed Date:  2004-01-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1099-104     Citation Subset:  AIM; IM    
Division of Cardiology, Wilford Hall Medical Center, United States Air Force, Lackland AFB, Tex 78236-5300, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Biological Markers / blood
C-Reactive Protein / metabolism*
Inflammation / blood,  complications
Middle Aged
Mitral Valve Stenosis / blood*,  therapy*,  ultrasonography
Rheumatic Heart Disease / blood*,  therapy*,  ultrasonography
Statistics as Topic
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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