| C-reactive protein does not impair insulin suppression of glucose release in primary hepatocytes. | |
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MedLine Citation:
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PMID: 20691575 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recent studies have suggested that CRP may interfere with insulin signaling in skeletal muscle and endothelial cells. The aim of this study was to determine whether highly purified CRP increased the rate of glucose appearance in primary hepatocytes in the absence or presence of insulin. Primary rat hepatocytes were provided glucose-free media containing 10 mM lactate, 1 mM pyruvate, 0, 1 or 10 nM insulin, and 0 or 10 μg/ml of purified CRP for 6h. Purified CRP did not increase glucose release in the absence of insulin and did not reduce the ability of insulin to suppress glucose release. |
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Authors:
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F Ellis; A Nivala; K T Pfaffenbach; C L Gentile; D Wang; Y Wei; M J Pagliassotti |
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Publication Detail:
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Type: Journal Article Date: 2010-08-05 |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 22 ISSN: 1590-3729 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 115-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523-1571, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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