Document Detail


C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease.
MedLine Citation:
PMID:  11703959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acute-phase reactant C-reactive protein (CRP) has emerged as an independent risk factor for coronary artery disease. Experimental and clinical studies provide evidence of anti-inflammatory effects of n-3 polyunsaturated fatty acids (PUFA) derived from fish. We have studied the effect of marine n-3 PUFA on CRP levels in 269 patients referred for coronary angiography because of clinical suspicion of coronary artery disease. All patients filled out a food questionnaire regarding fish intake. The n-3 PUFA content of granulocyte membranes was determined and the concentration of CRP in serum was measured using a highly sensitive assay. The results were related to angiographic findings. CRP was significantly higher in patients with significant coronary stenoses than in those with no significant angiographic changes (p <0.001), but the CRP levels were not associated with the number of diseased vessels. Subjects with CRP levels in the lower quartile had a significantly higher content of docosahexaenoic acid (DHA) in granulocytes than subjects with CRP levels in the upper quartile (p = 0.02), and in a multivariate linear regression analysis, DHA was independently correlated to CRP (R(2) = 0.179; p = 0.003). The inverse correlation between CRP and DHA may reflect an anti-inflammatory effect of DHA in patients with stable coronary artery disease and suggest a novel mechanism by which fish consumption may decrease the risk of coronary artery disease.
Authors:
T Madsen; H A Skou; V E Hansen; L Fog; J H Christensen; E Toft; E B Schmidt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  88     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2001-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-42     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Aalborg Hospital, Aalborg, Denmark. austrine@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
C-Reactive Protein / metabolism*
Coronary Angiography*
Coronary Stenosis / blood*
Cross-Sectional Studies
Diet*
Fatty Acids, Omega-3 / administration & dosage*,  pharmacology
Female
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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