| C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. | |
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MedLine Citation:
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PMID: 11703959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute-phase reactant C-reactive protein (CRP) has emerged as an independent risk factor for coronary artery disease. Experimental and clinical studies provide evidence of anti-inflammatory effects of n-3 polyunsaturated fatty acids (PUFA) derived from fish. We have studied the effect of marine n-3 PUFA on CRP levels in 269 patients referred for coronary angiography because of clinical suspicion of coronary artery disease. All patients filled out a food questionnaire regarding fish intake. The n-3 PUFA content of granulocyte membranes was determined and the concentration of CRP in serum was measured using a highly sensitive assay. The results were related to angiographic findings. CRP was significantly higher in patients with significant coronary stenoses than in those with no significant angiographic changes (p <0.001), but the CRP levels were not associated with the number of diseased vessels. Subjects with CRP levels in the lower quartile had a significantly higher content of docosahexaenoic acid (DHA) in granulocytes than subjects with CRP levels in the upper quartile (p = 0.02), and in a multivariate linear regression analysis, DHA was independently correlated to CRP (R(2) = 0.179; p = 0.003). The inverse correlation between CRP and DHA may reflect an anti-inflammatory effect of DHA in patients with stable coronary artery disease and suggest a novel mechanism by which fish consumption may decrease the risk of coronary artery disease. |
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Authors:
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T Madsen; H A Skou; V E Hansen; L Fog; J H Christensen; E Toft; E B Schmidt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 88 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-12 Completed Date: 2001-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1139-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Aalborg Hospital, Aalborg, Denmark. austrine@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged C-Reactive Protein / metabolism* Coronary Angiography* Coronary Stenosis / blood* Cross-Sectional Studies Diet* Fatty Acids, Omega-3 / administration & dosage*, pharmacology Female Humans Male Middle Aged Prospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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