Document Detail

C-reactive protein and cardiovascular disease: weighing the evidence.
MedLine Citation:
PMID:  16901413     Owner:  NLM     Status:  MEDLINE    
C-reactive protein (CRP) has been widely promoted as a strong, independent predictor of cardiovascular events and metabolic syndrome, both in general populations and in patients with clinical cardiovascular disease, and as a causal player in atherothrombosis. However, recent evidence shows that the association of CRP with cardiovascular events is weaker than previously thought, that it may be largely attributed to confounding by established causal risk factors, and that CRP is, therefore, probably not a clinically useful risk predictor. The lack of association of noncoding CRP gene polymorphisms (which determine different baseline CRP values) with coronary events or metabolic syndrome does not support a causal role for CRP, and most of the putatively proatherothrombotic in vitro effects claimed for CRP were caused by contaminants in commercial CRP preparations and not by CRP. Future clinical trials of specific CRP inhibitors now in development could directly test the contribution of CRP to pathogenesis of cardiovascular disease.
Gordon D O Lowe; Mark B Pepys
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  8     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-11     Completed Date:  2006-12-19     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-8     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / metabolism*
Cardiovascular Diseases / blood*,  epidemiology
Risk Factors
Severity of Illness Index
Grant Support
G7900510//Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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