| C-reactive protein as a marker of serious bacterial infections in hospitalized febrile infants. | |
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MedLine Citation:
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PMID: 19664100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the potential predictive power of C-reactive protein (CRP) as a marker of serious bacterial infection (SBI) in hospitalized febrile infants aged < or =3 months. PATIENTS AND METHODS: Data on blood CRP levels were collected prospectively on admission for all infants aged < or =3 months who were hospitalized for fever from 2005 to 2008. The patients were divided into two groups by the presence or absence of findings of SBI. RESULTS: A total of 892 infants met the inclusion criteria, of whom 102 had a SBI. Mean CRP level was significantly higher in the infants who had a bacterial infection than in those who did not (5.3 +/- 6.3 mg/dL vs. 1.3 +/- 2.2 mg/dL, p < 0.001). The area under the ROC curve (AUC) was 0.74 (95% CI: 0.67-0.80) for CRP compared to 0.70 (95% CI: 0.64-0.76) for white blood cell (WBC) count. When analyses were limited to predicting bacteremia or meningitis only, the AUCs for CRP and WBC were 0.81 (95% CI: 0.66-0.96) and 0.63 (95% CI: 0.42-0.83), respectively. CONCLUSION: C-reactive protein is a valuable laboratory test in the assessment of febrile infants aged < or =3 months old and may serve as a better diagnostic marker of SBI than total WBC count. |
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Authors:
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Efraim Bilavsky; Havatzelet Yarden-Bilavsky; Shai Ashkenazi; Jacob Amir |
Publication Detail:
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Type: Journal Article Date: 2009-08-06 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 98 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-07 Completed Date: 2009-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1776-80 Citation Subset: IM |
Affiliation:
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Department of Paediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel. yoji@netvision.net.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Bacterial Infections / blood, diagnosis* Biological Markers / blood C-Reactive Protein / analysis* Female Fever / blood, microbiology* Hospitalization Humans Infant Infant, Newborn Leukocyte Count Logistic Models Male Observation Prospective Studies Sensitivity and Specificity Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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