Document Detail

C-reactive protein as a marker of serious bacterial infections in hospitalized febrile infants.
MedLine Citation:
PMID:  19664100     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the potential predictive power of C-reactive protein (CRP) as a marker of serious bacterial infection (SBI) in hospitalized febrile infants aged < or =3 months. PATIENTS AND METHODS: Data on blood CRP levels were collected prospectively on admission for all infants aged < or =3 months who were hospitalized for fever from 2005 to 2008. The patients were divided into two groups by the presence or absence of findings of SBI. RESULTS: A total of 892 infants met the inclusion criteria, of whom 102 had a SBI. Mean CRP level was significantly higher in the infants who had a bacterial infection than in those who did not (5.3 +/- 6.3 mg/dL vs. 1.3 +/- 2.2 mg/dL, p < 0.001). The area under the ROC curve (AUC) was 0.74 (95% CI: 0.67-0.80) for CRP compared to 0.70 (95% CI: 0.64-0.76) for white blood cell (WBC) count. When analyses were limited to predicting bacteremia or meningitis only, the AUCs for CRP and WBC were 0.81 (95% CI: 0.66-0.96) and 0.63 (95% CI: 0.42-0.83), respectively. CONCLUSION: C-reactive protein is a valuable laboratory test in the assessment of febrile infants aged < or =3 months old and may serve as a better diagnostic marker of SBI than total WBC count.
Efraim Bilavsky; Havatzelet Yarden-Bilavsky; Shai Ashkenazi; Jacob Amir
Publication Detail:
Type:  Journal Article     Date:  2009-08-06
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1776-80     Citation Subset:  IM    
Department of Paediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
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MeSH Terms
Analysis of Variance
Bacterial Infections / blood,  diagnosis*
Biological Markers / blood
C-Reactive Protein / analysis*
Fever / blood,  microbiology*
Infant, Newborn
Leukocyte Count
Logistic Models
Prospective Studies
Sensitivity and Specificity
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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