Document Detail

C-reactive protein and aetiological subtypes of cerebral infarction.
MedLine Citation:
PMID:  18810599     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We have sought to relate C-reactive protein (CRP), a peripheral marker of inflammation frequently elevated in stroke patients, with aetiology and prognosis of acute cerebral infarction. PATIENTS AND METHODS: Patients were included after a first-ever CT/MR documented cerebral infarction. CRP was measured from blood samples taken within the 6th hour of the onset. Titres of C-reactive protein were stratified in quartiles. Aetiology of stroke was from TOAST criteria. Prognosis was mortality within 14 days of stroke. RESULTS: The study included 648 stroke patients. They were 335 women and 313 men, with a mean age of 70.3 years (median 72). CRP quartiles were mostly increased in cardioembolic strokes, After logistic regression analysis CRP remained an independent factor of 14-day mortality. CONCLUSIONS: Our study suggests that in the acute phase of the cerebral infarction CRP might be either a marker of cardioembolism or a predictive factor for short-term mortality.
Alessandro Terruzzi; Laura Valente; Roberto Mariani; Luca Moschini; Massimo Camerlingo
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Publication Detail:
Type:  Journal Article     Date:  2008-09-20
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  29     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-23     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Stroke Unit, Policlinico San Marco, Osio Sotto (Bergamo), Italy.
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MeSH Terms
Acute Disease
Aged, 80 and over
Biological Markers / analysis,  blood
C-Reactive Protein / analysis,  metabolism*
Cerebral Infarction / blood,  diagnosis*,  etiology*
Early Diagnosis
Inflammation / blood,  complications,  diagnosis
Intracranial Embolism / blood,  diagnosis
Middle Aged
Predictive Value of Tests
Time Factors
Up-Regulation / physiology
Young Adult
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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