Document Detail

C-reactive protein (CRP) levels do not reflect disease status in patients with multiple myeloma.
MedLine Citation:
PMID:  8339052     Owner:  NLM     Status:  MEDLINE    
It has recently been suggested that a combination of C-Reactive Protein (CRP) and beta-2-microglobulin (beta 2M) can be used to devise a simple prognostic model for patients with multiple myeloma. In this study we have measured serum beta 2M, CRP and thymidine kinase (STK) in a series of 215 samples to determine their value as a monitor of disease status. A longitudinal study was also performed with 6 individual patients. CRP levels did not correlate with disease status. The mean of the stable (23.62 mg/L) and the progressive disease 23.64 mg/L) groups were almost identical (t = 0.003; p = NS) with ranges of < 5-150 mg/L and < 5-100 mg/L respectively. There was no correlation between CRP and STK (r = 0.11) or CRP and beta 2M (r = 0.05). In longitudinal studies, CRP did not necessarily reflect changes in disease activity. We conclude that CRP measurements are not valuable as a monitor of disease activity in patients with myeloma.
R D Brown; L Snowdon; E Uhr; J Gibson; D Joshua
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  9     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Haematology Department, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
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MeSH Terms
C-Reactive Protein / analysis*
Interleukin-6 / blood
Longitudinal Studies
Multiple Myeloma / blood*
Prospective Studies
Reg. No./Substance:
0/Interleukin-6; 9007-41-4/C-Reactive Protein

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