| C-reactive protein (CRP) levels do not reflect disease status in patients with multiple myeloma. | |
| | |
MedLine Citation:
|
PMID: 8339052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has recently been suggested that a combination of C-Reactive Protein (CRP) and beta-2-microglobulin (beta 2M) can be used to devise a simple prognostic model for patients with multiple myeloma. In this study we have measured serum beta 2M, CRP and thymidine kinase (STK) in a series of 215 samples to determine their value as a monitor of disease status. A longitudinal study was also performed with 6 individual patients. CRP levels did not correlate with disease status. The mean of the stable (23.62 mg/L) and the progressive disease 23.64 mg/L) groups were almost identical (t = 0.003; p = NS) with ranges of < 5-150 mg/L and < 5-100 mg/L respectively. There was no correlation between CRP and STK (r = 0.11) or CRP and beta 2M (r = 0.05). In longitudinal studies, CRP did not necessarily reflect changes in disease activity. We conclude that CRP measurements are not valuable as a monitor of disease activity in patients with myeloma. |
| | |
Authors:
|
R D Brown; L Snowdon; E Uhr; J Gibson; D Joshua |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Leukemia & lymphoma Volume: 9 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 1993 Apr |
Date Detail:
|
Created Date: 1993-09-02 Completed Date: 1993-09-02 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 509-12 Citation Subset: IM |
Affiliation:
|
Haematology Department, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
C-Reactive Protein
/
analysis* Humans Interleukin-6 / blood Longitudinal Studies Multiple Myeloma / blood* Prospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-6; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Granulocyte-macrophage colony stimulating factor in autologous bone marrow transplantation: augmenta...
Next Document: Waldenström's macroglobulinaemia terminating in acute myeloid leukaemia: report of a case and revie...