Document Detail


C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism.
MedLine Citation:
PMID:  18829218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: C-reactive protein (CRP) is a marker of cardiovascular disease. The objective was to determine if abdominal aortic aneurysm (AAA) and CRP serum concentration and its CRP gene are associated.
METHODS AND RESULTS: AAA patients and AAA negative controls were recruited. CRP concentration was measured and the single nucleotide polymorphism (SNP), rs3091244, assessed. AAA cases were divided into those measuring 30-55 mm and >55 mm in diameter, to assess correlation of CRP with AAA size. A total of 248 (227 male) cases and 400 (388 male) controls were included. CRP concentration was higher in cases (385.0 microl/dL [310.4-442.8] vs 180.3 microl/dL [168.1-196.9]; P < .0001). It was higher in large aneurysms (685.7 microl/dL [511.8-1083.0] vs 291.0 microl/dL [223.6-349.6]; P < .0001), with significant correlation observed to size (r = 0.37, P < .0001). CC was the most common SNP genotype with no difference in distribution (P = .43) between cases and controls. No difference existed in CRP for each genotype in the overall cohort (P = .17), cases (P = .18) and controls (P = .19).
CONCLUSION: The results demonstrate that CRP production may be related to the presence of AAA, especially in advanced disease. The serum concentration of CRP does not appear to be influenced by the functional SNP of the CRP gene, which also appears to have no association with AAA formation.
Authors:
Stephen A Badger; Chee V Soong; Mark E O'Donnell; Caroline Mercer; Ian S Young; Anne E Hughes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-01
Journal Detail:
Title:  Journal of vascular surgery     Volume:  49     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-02-19     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-84     Citation Subset:  IM    
Affiliation:
Vascular and Endovascular Surgery Department, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom. StephenBadger@btinternet.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Aortic Aneurysm, Abdominal / genetics,  immunology*,  pathology
Biological Markers / blood
C-Reactive Protein / genetics,  metabolism*
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide*
Risk Factors
Up-Regulation
Chemical
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein
Comments/Corrections
Comment In:
J Vasc Surg. 2009 Jul;50(1):240; author reply 240-1   [PMID:  19563984 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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