| C-fos expression and electrolytic lesions studies reveal activation of the posterior region of locus coeruleus during hemorrhage induced hypotension. | |
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MedLine Citation:
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PMID: 9675311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bilateral electrolytic lesions in the rat Locus Coeruleus (LC) were made one or seven days before experimentation. Four hemorrhage sessions, withdrawing 10% of the blood volume per session, were performed in 5 min intervals in freely moving rats. Blood pressure (BP) was not affected by the lesions and did not drop in the first, but decreased in all subsequent hemorrhages. The decrease in BP in animals with lesion in the anterior LC was similar to the controls. However, animals with lesions in the posterior LC showed an enhanced decrease in BP during the second hemorrhage, in acute and chronic experiments. Expression of Fos protein was studied to investigate the relationship between LC activity and BP changes. Two hours after the second hemorrhage, the brains were removed and processed for Fos immunocytochemistry. Hemorrhage increased the number of Fos immunoreactive neurons mainly in the posterior LC. We conclude that (1) the LC does may not play a role in cardiovascular control during resting, but seems to mediate compensatory cardiovascular mechanisms in situations of hypovolemia; and (2) the posterior LC, but not the anterior, plays a pressor role during hemorrhage. |
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Authors:
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J A Anselmo-Franci; V L Peres-Polon; V M da Rocha-Barros; E R Moreira; C R Franci; M J Rocha |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 799 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-09-25 Completed Date: 1998-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 278-84 Citation Subset: IM |
Copyright Information:
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Copyright 1998 Elsevier Science B.V. All rights reserved. |
Affiliation:
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Department of Physiology, Dental School of Ribeirão Preto, University of São Paulo, Av. Café s/n, CEP 14040-904-Ribeirão Preto, São Paulo, Brazil. jaafranc@usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Blood Volume / physiology Brain / metabolism Hemorrhage / complications* Hypotension / etiology*, metabolism, physiopathology* Immunohistochemistry Locus Coeruleus / pathology, physiopathology* Male Neurons / metabolism, physiology Proto-Oncogene Proteins c-fos / metabolism* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-fos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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