Document Detail


C-fos and c-myc modulation, mitogenic effect and Ia expression in the P388D1 murine macrophage line treated by immunomodifiers.
MedLine Citation:
PMID:  1426675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate whether the early modulation of the c-fos and c-myc oncogenes could give some orientation to the impact of immunomodulators on the monocyte-macrophage lineage. In order to work in a homogeneous system we used the P388D1 mouse macrophage cell-line which is considered as an almost mature macrophage. When P388D1 cells were stimulated by LPS, interferon-gamma or the association of both compounds, no direct correlation could be found between the modulation of DNA synthesis and the early expression of the c-fos and c-myc oncogenes. The positive regulation of Ia antigen expression seemed to correlate with the absence of induction of c-fos oncogene.
Authors:
M M Teyssier; Y C Le Garrec; E H Jullian; P J Michel; A J Pompidou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developments in biological standardization     Volume:  77     ISSN:  0301-5149     ISO Abbreviation:  Dev. Biol. Stand.     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-14     Completed Date:  1992-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0427140     Medline TA:  Dev Biol Stand     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Affiliation:
Lab. d'Histologie, Cytogénétique, Faculté de Médecine Cochin-Port-Royal, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology*
Animals
DNA Replication / drug effects
Endotoxins / pharmacology*
Gene Expression Regulation, Neoplastic / drug effects*
Genes, MHC Class II / drug effects*
Genes, fos / drug effects*
Genes, myc / drug effects*
Interferon-gamma, Recombinant / pharmacology*
Leukemia P388 / genetics,  pathology*
Lipopolysaccharides
Macrophage Activation / drug effects*
Mice
Tetradecanoylphorbol Acetate / pharmacology
Tumor Cells, Cultured / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Endotoxins; 0/Interferon-gamma, Recombinant; 0/Lipopolysaccharides; 16561-29-8/Tetradecanoylphorbol Acetate; 67924-63-4/endotoxin, Escherichia coli

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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