Document Detail

C-fos and c-myc modulation, mitogenic effect and Ia expression in the P388D1 murine macrophage line treated by immunomodifiers.
MedLine Citation:
PMID:  1426675     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate whether the early modulation of the c-fos and c-myc oncogenes could give some orientation to the impact of immunomodulators on the monocyte-macrophage lineage. In order to work in a homogeneous system we used the P388D1 mouse macrophage cell-line which is considered as an almost mature macrophage. When P388D1 cells were stimulated by LPS, interferon-gamma or the association of both compounds, no direct correlation could be found between the modulation of DNA synthesis and the early expression of the c-fos and c-myc oncogenes. The positive regulation of Ia antigen expression seemed to correlate with the absence of induction of c-fos oncogene.
M M Teyssier; Y C Le Garrec; E H Jullian; P J Michel; A J Pompidou
Related Documents :
21358275 - Rev-ing up post-transcriptional hiv-1 rna expression.
21423215 - Camptothecin-induced downregulation of mll5 contributes to the activation of tumor supp...
21270405 - Cxcr4 expression on activated b cells is downregulated by cd63 and il-21.
7787735 - Differential expression of c-fos proto-oncogene in two subclones derived from a human o...
12185095 - Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm duri...
10215765 - Internalization of constitutive desmogleins with the subsequent induction of desmoglein...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developments in biological standardization     Volume:  77     ISSN:  0301-5149     ISO Abbreviation:  Dev. Biol. Stand.     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-14     Completed Date:  1992-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0427140     Medline TA:  Dev Biol Stand     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Lab. d'Histologie, Cytogénétique, Faculté de Médecine Cochin-Port-Royal, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adjuvants, Immunologic / pharmacology*
DNA Replication / drug effects
Endotoxins / pharmacology*
Gene Expression Regulation, Neoplastic / drug effects*
Genes, MHC Class II / drug effects*
Genes, fos / drug effects*
Genes, myc / drug effects*
Interferon-gamma, Recombinant / pharmacology*
Leukemia P388 / genetics,  pathology*
Macrophage Activation / drug effects*
Tetradecanoylphorbol Acetate / pharmacology
Tumor Cells, Cultured / drug effects,  metabolism
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Endotoxins; 0/Interferon-gamma, Recombinant; 0/Lipopolysaccharides; 16561-29-8/Tetradecanoylphorbol Acetate; 67924-63-4/endotoxin, Escherichia coli

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  IMOCUR stimulates production of immunoglobulins; preliminary results concerning a correlation betwee...
Next Document:  Immunotoxicology of immunomodulators.