Document Detail

C-fos and c-jun expressions in nitric oxide synthase immunoreactive neurons in the lateral geniculate nucleus of experimental glaucomatous rats.
MedLine Citation:
PMID:  12021818     Owner:  NLM     Status:  MEDLINE    
The present study was initiated to investigate the expressions of c-fos and c-jun in nitric oxide synthase immunoreactive neurons and their possible roles in the lateral geniculate nucleus (LGN) of glaucomatous rats. An experimental one-eye glaucoma model was created by cauterisation of the limbal-derived veins. Animals were killed by cardiac perfusion, and brains containing the LGN were removed and processed for c-fos, c-jun and neuronal nitric oxide synthase (nNOS) immunohistochemistry. No c-fos or c-jun immunoreactivity was observed in the LGN of control rats. In the glaucomatous rats, expression of c-fos and c-jun was induced bilaterally in the ventral LGN (vLGN) as early as 2 h postoperation. The number of c-fos-immunopositive cells increased at 1 and 2 days postoperation in both the lateral and medial subdivisions of the vLGN (vLGN-l and vLGN-m). Thereafter, the expression decreased and was totally absent at 1 and 2 weeks. No c-fos was induced in the dorsal LGN (dLGN). C-jun-immunopositive cells were mainly localised in the intergeniculate leaflet and vLGN. Few neurons were observed in the dLGN. The number of c-jun-immunopositive cells decreased at 1 and 2 weeks postoperation. Some of the c-fos- and c-jun-immunopositive cells were also nNOS immunopositive. The present results reveal that glaucoma activates the expressions of immediate early genes (IEGs) in some cells of the LGN. It is postulated that they may play important roles in the pathologic processes of glaucoma. The relationship between these IEGs and nitric oxide was also discussed.
Xu Wang; Samuel Sam-Wah Tay; Yee-Kong Ng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-03-19
Journal Detail:
Title:  Experimental brain research     Volume:  144     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-21     Completed Date:  2002-09-04     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  IM    
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MeSH Terms
Cell Count
Gene Expression Regulation, Enzymologic / physiology
Geniculate Bodies / enzymology*,  pathology,  physiopathology
Glaucoma / enzymology*,  pathology,  physiopathology
Intraocular Pressure / physiology
Nerve Degeneration / enzymology,  pathology,  physiopathology
Neurons / metabolism*,  pathology
Nitric Oxide / metabolism
Nitric Oxide Synthase / metabolism*
Proto-Oncogene Proteins c-fos / metabolism
Proto-Oncogene Proteins c-jun / metabolism
Rats, Wistar
Retinal Ganglion Cells / pathology*
Visual Pathways / pathology,  physiopathology*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 31C4KY9ESH/Nitric Oxide; EC Oxide Synthase

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