Document Detail


C fiber responses of wide dynamic range neurons in the spinal dorsal horn.
MedLine Citation:
PMID:  9584391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Responses of wide dynamic range neurons in the spinal dorsal horn to input from C fibers with various conduction velocities were analyzed. The wide dynamic range neurons studied were located in the laminae IV-VI of the spinal dorsal horn. The C fiber response to stimulation of the superficial peroneal nerve consisted of three components: early, middle, and late. The separation into three components was found to be caused by asynchronous volleys in three different classes of C fibers in the superficial peroneal nerve. The phenomenon of windup was observed to occur always in the late component, frequently in the middle component, and to a far lesser extent in the early component. The early component was augmented by sciatic nerve compression, indicating that the initial part of the C fiber response is suppressed within the spinal cord by an inhibitory effect of A fiber afferent volleys. An intravenous administration of a specific N-methyl-D-aspartate receptor antagonist, MK-801 hydrogen maleate, significantly suppressed the middle and late components of the C fiber response, although the effect on the early component was insignificant. Thus, one can infer that the hyperexcitability of wide dynamic range neurons to input from early components of cutaneous C fiber stimuli will yield hyperpathic symptoms such as paresthesia, hyperalgesia, and allodynia associated with damaged peripheral nerves, and that learning how to inhibit the hyperexcitability of wide dynamic range neurons to input from early components of C fiber stimuli will lead to the curative treatment for neuropathic pain.
Authors:
F Hanai
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-28     Completed Date:  1998-05-28     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-67     Citation Subset:  AIM; IM    
Affiliation:
Department of Orthopaedic Surgery, Inabe Kousei Hospital, Mie, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Dizocilpine Maleate / pharmacology
Electric Stimulation
Excitatory Amino Acid Antagonists / pharmacology
Female
Male
Nerve Fibers / drug effects,  physiology*
Sciatic Nerve
Spine / innervation*
Chemical
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 77086-22-7/Dizocilpine Maleate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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