Document Detail

C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.
MedLine Citation:
PMID:  10896158     Owner:  NLM     Status:  MEDLINE    
Caenorhabditis elegans modulates its locomotory rate in response to its food, bacteria, in two ways. First, well-fed wild-type animals move more slowly in the presence of bacteria than in the absence of bacteria. This basal slowing response is mediated by a dopamine-containing neural circuit that senses a mechanical attribute of bacteria and may be an adaptive mechanism that increases the amount of time animals spend in the presence of food. Second, food-deprived wild-type animals, when transferred to bacteria, display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food. This experience-dependent response is mediated by serotonergic neurotransmission and is potentiated by fluoxetine (Prozac). The basal and enhanced slowing responses are distinct and separable neuromodulatory components of a genetically tractable paradigm of behavioral plasticity.
E R Sawin; R Ranganathan; H R Horvitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  26     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-07     Completed Date:  2000-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  619-31     Citation Subset:  IM; S    
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
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MeSH Terms
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins*
Catalase / genetics
Dopamine / pharmacology,  physiology*
Escherichia coli / physiology
Fluoxetine / pharmacology
Food Deprivation / physiology
Fungal Proteins / genetics
Helminth Proteins / genetics
Mechanoreceptors / physiology
Mixed Function Oxygenases*
Motor Activity / drug effects,  physiology*
Mutation / physiology
Neurons / physiology
Serotonin / physiology*
Serotonin Uptake Inhibitors / pharmacology
Time Factors
Trans-Activators / genetics
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Fungal Proteins; 0/Helminth Proteins; 0/Serotonin Uptake Inhibitors; 0/Trans-Activators; 0/cat-2 protein, C elegans; 50-67-9/Serotonin; 54910-89-3/Fluoxetine; EC 1.-/Mixed Function Oxygenases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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