| C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. | |
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MedLine Citation:
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PMID: 10896158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caenorhabditis elegans modulates its locomotory rate in response to its food, bacteria, in two ways. First, well-fed wild-type animals move more slowly in the presence of bacteria than in the absence of bacteria. This basal slowing response is mediated by a dopamine-containing neural circuit that senses a mechanical attribute of bacteria and may be an adaptive mechanism that increases the amount of time animals spend in the presence of food. Second, food-deprived wild-type animals, when transferred to bacteria, display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food. This experience-dependent response is mediated by serotonergic neurotransmission and is potentiated by fluoxetine (Prozac). The basal and enhanced slowing responses are distinct and separable neuromodulatory components of a genetically tractable paradigm of behavioral plasticity. |
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Authors:
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E R Sawin; R Ranganathan; H R Horvitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuron Volume: 26 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-08-07 Completed Date: 2000-08-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 619-31 Citation Subset: IM; S |
Affiliation:
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Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins* Catalase / genetics Dopamine / pharmacology, physiology* Environment* Escherichia coli / physiology Fluoxetine / pharmacology Food Deprivation / physiology Fungal Proteins / genetics Helminth Proteins / genetics Mechanoreceptors / physiology Mixed Function Oxygenases* Motor Activity / drug effects, physiology* Mutation / physiology Neurons / physiology Serotonin / physiology* Serotonin Uptake Inhibitors / pharmacology Time Factors Trans-Activators / genetics |
| Grant Support | |
ID/Acronym/Agency:
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GM24663/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Fungal Proteins; 0/Helminth Proteins; 0/Serotonin Uptake Inhibitors; 0/Trans-Activators; 0/cat-2 protein, C elegans; 50-67-9/Serotonin; 54910-89-3/Fluoxetine; EC 1.-/Mixed Function Oxygenases; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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