| The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis. | |
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MedLine Citation:
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PMID: 19906858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell migration is a common event during organogenesis, yet little is known about how migration is temporally coordinated with organ development. We are investigating stage-specific programs of cell migration using the linker cell (LC), a migratory cell crucial for male gonadogenesis of C. elegans. During the L3 and L4 larval stages of wild-type males, the LC undergoes changes in its position along the migratory route, in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology. We have identified the tailless homolog nhr-67 as a cell-autonomous, stage-specific regulator of timing in LC migration programs. In nhr-67-deficient animals, each of the L3 and L4 stage changes is either severely delayed or never occurs, yet LC development before the early L3 stage or after the mid-L4 stage occurs with normal timing. We propose that there is a basal migration program utilized throughout LC migration that is modified by stage-specific regulators such as nhr-67. |
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Authors:
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Mihoko Kato; Paul W Sternberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 136 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2009-12-22 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 3907-15 Citation Subset: IM |
Affiliation:
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HHMI and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Caenorhabditis elegans / cytology*, embryology, genetics, growth & development, physiology* Caenorhabditis elegans Proteins / genetics, physiology* Cell Movement / genetics* Embryo, Nonmammalian Larva / cytology, physiology Male Models, Biological Organogenesis / genetics* Plasmids / genetics RNA Interference Receptors, Cytoplasmic and Nuclear / genetics, physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Nhr-67 protein, C elegans; 0/Receptors, Cytoplasmic and Nuclear |
| Comments/Corrections | |
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