Document Detail


The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis.
MedLine Citation:
PMID:  19906858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell migration is a common event during organogenesis, yet little is known about how migration is temporally coordinated with organ development. We are investigating stage-specific programs of cell migration using the linker cell (LC), a migratory cell crucial for male gonadogenesis of C. elegans. During the L3 and L4 larval stages of wild-type males, the LC undergoes changes in its position along the migratory route, in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology. We have identified the tailless homolog nhr-67 as a cell-autonomous, stage-specific regulator of timing in LC migration programs. In nhr-67-deficient animals, each of the L3 and L4 stage changes is either severely delayed or never occurs, yet LC development before the early L3 stage or after the mid-L4 stage occurs with normal timing. We propose that there is a basal migration program utilized throughout LC migration that is modified by stage-specific regulators such as nhr-67.
Authors:
Mihoko Kato; Paul W Sternberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  136     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2009-12-22     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3907-15     Citation Subset:  IM    
Affiliation:
HHMI and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Caenorhabditis elegans / cytology*,  embryology,  genetics,  growth & development,  physiology*
Caenorhabditis elegans Proteins / genetics,  physiology*
Cell Movement / genetics*
Embryo, Nonmammalian
Larva / cytology,  physiology
Male
Models, Biological
Organogenesis / genetics*
Plasmids / genetics
RNA Interference
Receptors, Cytoplasmic and Nuclear / genetics,  physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Nhr-67 protein, C elegans; 0/Receptors, Cytoplasmic and Nuclear
Comments/Corrections

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