Document Detail

The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis.
MedLine Citation:
PMID:  19906858     Owner:  NLM     Status:  MEDLINE    
Cell migration is a common event during organogenesis, yet little is known about how migration is temporally coordinated with organ development. We are investigating stage-specific programs of cell migration using the linker cell (LC), a migratory cell crucial for male gonadogenesis of C. elegans. During the L3 and L4 larval stages of wild-type males, the LC undergoes changes in its position along the migratory route, in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology. We have identified the tailless homolog nhr-67 as a cell-autonomous, stage-specific regulator of timing in LC migration programs. In nhr-67-deficient animals, each of the L3 and L4 stage changes is either severely delayed or never occurs, yet LC development before the early L3 stage or after the mid-L4 stage occurs with normal timing. We propose that there is a basal migration program utilized throughout LC migration that is modified by stage-specific regulators such as nhr-67.
Mihoko Kato; Paul W Sternberg
Related Documents :
16988378 - Nuclear transfer in nonhuman primates.
19112878 - Human somatic cell nuclear transfer.
3731278 - Cell death during normal gastrulation in the newt, cynops pyrrhogaster.
14764688 - The cytoplasmic domain of ig alpha is necessary and sufficient to support efficient ear...
9581828 - Induction of apoptosis in mcf-7:ws8 breast cancer cells by beta-lapachone.
25225958 - Cell surface marker mediated purification of ips cell intermediates from a reprogrammab...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  136     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2009-12-22     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3907-15     Citation Subset:  IM    
HHMI and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Genetically Modified
Caenorhabditis elegans / cytology*,  embryology,  genetics,  growth & development,  physiology*
Caenorhabditis elegans Proteins / genetics,  physiology*
Cell Movement / genetics*
Embryo, Nonmammalian
Larva / cytology,  physiology
Models, Biological
Organogenesis / genetics*
Plasmids / genetics
RNA Interference
Receptors, Cytoplasmic and Nuclear / genetics,  physiology*
Time Factors
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Nhr-67 protein, C elegans; 0/Receptors, Cytoplasmic and Nuclear

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.
Next Document:  Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos.