| The C. elegans cell cycle: overview of molecules and mechanisms. | |
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MedLine Citation:
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PMID: 15576926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nematode C. elegans provides an animal model that allows for genetic dissection of cell cycle regulation in the context of development. Processes such as progression through meiotic prophase, spindle function, chromosome segregation, and cytokinesis are attractive topics to study in the worm, because of their relative visibility and susceptibility to RNA interference. In addition, the reproducible cell lineage greatly helps the identification and characterization of mutants that affect cell cycle entry or exit during larval development. This chapter looks at cell division as an integral part of C. elegans development, describes how it can be studied in the worm and summarizes some of the conserved cell cycle components described to date. |
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Authors:
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Sander van den Heuvel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 296 ISSN: 1064-3745 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2005 |
Date Detail:
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Created Date: 2004-12-03 Completed Date: 2005-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 51-67 Citation Subset: IM |
Affiliation:
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Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / cytology*, genetics, growth & development, physiology Caenorhabditis elegans Proteins / physiology Cell Cycle / physiology* Cell Cycle Proteins / physiology Cell Division Genomics Meiosis Models, Animal |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Cell Cycle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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