Document Detail

C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations.
MedLine Citation:
PMID:  17237778     Owner:  NLM     Status:  MEDLINE    
During nervous system development, a small number of conserved guidance cues and receptors regulate many axon trajectories. How could a limited number of cues and receptors regulate such complex projection patterns? One way is to modulate receptor function. Here we show that the Caenorhabditis elegans kinesin-related protein VAB-8L, which is necessary and sufficient for posterior cell and growth-cone migrations, directs these migrations by regulating the levels of the guidance receptor SAX-3 (also known as robo). Genetic experiments indicate that VAB-8L and the Rac guanine nucleotide exchange factor activity of UNC-73 (trio) increase the ability of the SLT-1 (slit) and UNC-6 (netrin) guidance pathways to promote posterior guidance. The observations of higher SAX-3 receptor abundance in animals with increasing amounts of VAB-8L, and of physical interactions between UNC-73 and both VAB-8L and the intracellular domain of the SAX-3, support a model whereby VAB-8L directs cell and growth-cone migrations by promoting localization of guidance receptors to the cell surface.
Natsuko Watari-Goshima; Ken-ichi Ogura; Fred W Wolf; Yoshio Goshima; Gian Garriga
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-01-21
Journal Detail:
Title:  Nature neuroscience     Volume:  10     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-04-03     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-76     Citation Subset:  IM    
Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-3204, USA.
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MeSH Terms
Caenorhabditis elegans
Caenorhabditis elegans Proteins / genetics,  metabolism*
Cell Differentiation / physiology
Cell Movement / physiology*
Growth Cones / metabolism*,  ultrastructure
Nerve Tissue Proteins / genetics,  metabolism*
Nervous System / cytology,  embryology*,  metabolism
Receptors, Immunologic / genetics,  metabolism*
rac GTP-Binding Proteins / genetics,  metabolism
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Nerve Tissue Proteins; 0/Receptors, Immunologic; 0/UNC-6 protein, C elegans; 0/UNC-73 protein, C elegans; 0/VAB-8 protein, C elegans; 0/roundabout protein; 0/slt-1 protein, C elegans; EC GTP-Binding Proteins

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