Document Detail

C cells in the thyroid of pinealectomized rats.
MedLine Citation:
PMID:  12754586     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study quantitatively C cells in the thyroids of non-isogenic rats to determine the possible effects of pinealectomy on the number of these cells, and consequently on the synthesis and secretion of calcitonin. METHODS: Twenty male rats of an outbred strain (200-300 g) were used in the present study. One group of 10 animals was pinealectomized 50 days prior to sacrifice. Thyroid tissue was stained for calcitonin (Dako Corporation) at a 1:1500 dilution. The number of C cells observed was expressed as number of cells/cm . Data were analyzed statistically by Mann-Whitney test. RESULTS: The number of C cells in pinealectomized and normal animals ranged from 489 to 2084 per cm and 227 to 1584 per cm , respectively, a difference that was statistically significant (P <0.05). CONCLUSIONS: These results showed consistent differences in the number of C cells after pinealectomy when compared to controls. We believe that pinealectomy increases the number of C cells in the rat thyroid.
Marcus Aurelho de Lima; Lilian Margareth Biagioni de Lima; Leandro Luís Lopes Freitas; Patrícia Fernanda Toledo Barbosa; Maria de Fátima Borges; Luiz Reis; Gilberto de Araujo Pereira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-04-30
Journal Detail:
Title:  Revista do Hospital das Clínicas     Volume:  58     ISSN:  0041-8781     ISO Abbreviation:  Rev Hosp Clin Fac Med Sao Paulo     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-05-19     Completed Date:  2003-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0415246     Medline TA:  Rev Hosp Clin Fac Med Sao Paulo     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
Faculty of Medicine of the Triângulo Mineiro, University of Uberaba, Brazil.
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MeSH Terms
Analysis of Variance
Calcitonin / secretion
Cell Count
Pineal Gland / physiology,  surgery*
Rats, Wistar
Statistics, Nonparametric
Thyroid Gland / cytology*
Reg. No./Substance:

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